homozygote


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homozygote

 [ho″mo-zi´gōt]
an individual exhibiting homozygosity.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ho·mo·zy·gote

(hō'mō-zī'gōt),
A homozygous individual.
[homo- + G. zygōtos, yoke]
Farlex Partner Medical Dictionary © Farlex 2012

homozygote

(hō′mō-zī′gōt′, -mə-, hŏm′ə-)
n.
An organism that has the same alleles at a particular gene locus on homologous chromosomes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

ho·mo·zy·gote

(hō'mō-zī'gōt)
A homozygous individual.
[homo- + G. zygōtos, yoke]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

homozygote

an individual containing two identical forms of the same GENE in all DIPLOID (1) cells that is capable of pure breeding. Thus if gene A has two alleles, A 1 and A 2, two homozygous types are possible: A1/A1 and A 2/A2. Compare HETEROZYGOTE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
One of ten samples was a A1A1 homozygote for mutated allele, three of ten were A2A2 homozygotes for wild type allele and six were A1A2 heterozygotes for mutated allele.
Genotype frequencies of RAD51 135 G>C polymorphism in male and female patients with rectal cancer Sex, N (%) Genotype/allele All, N (%) Male Female Homozygote CC 3 (2.9) 1 (1.4) 2 (6.7) Homozygote GG 75 (72.8) 55 (75.3) 20 (66.7) Heterozygote GC 25 (24.3) 17 (23.3) 8 (26.7) Total 103 73 (70.9) 30 (29.1) Table 3.
In the present study, all the individuals were divided into three groups according to the results of CYP3A4*1G genotyping, including 143 (71.5%) with wild-type homozygote (GG), 47 (23.5%) with mutant heterozygote (GA), and 10 (5.0%) with mutant homozygote (AA).
Results revealed significant differences in the distribution of homozygote TT genotype between patients with one and three stenotic vessels (p = 0.028), indicating the effect of this polymorphism on the severity of CAD.
The genotypes of 5-HTTLPR were divided into three groups by PCR using specific primers: homozygote for SS, homozygote for LL, and heterozygote for LS.
A significant increased risk was identified in the homozygote model (GG versus AA: OR=1.43, 95% CI 1.06-1.93, [P.sub.H] = 0.27), while no obvious association was observed in other models (G versus A: OR= 1.08, 95% CI 0.96-1.22, [P.sub.H] = 0.75; GA versus AA: OR = 0.86, 95% CI 0.56-1.33, [P.sub.H] < 0.001; GG + GA versus AA: OR = 0.97, 95% CI 0.78-1.20, [P.sub.H] = 0.064; and GG versus GA + AA: OR= 1.28, 95% CI 0.64-2.53, [P.sub.H] = 0.001).
Rationalizing why faster rates improve genotyping of homozygotes in small amplicons is more difficult.
In the codominant model of heterozygote vs wild homozygote, the associations between rs2280091 and rs528557 polymorphisms and asthma in children were significant (OR=1.91, 95%CI=1.24-2.94, and OR=2.92, 95%CI=1.33-6.39, respectively).
It would be particularly beneficial for animals with long gestation period to save the time required for breeding for the production of homozygote animals from the verified heterozygotes.
Results: We have detected a new homozygote mutation of WAS gene (NM_000377.2 p.M393lfs*102(c.1178dupT) in these two patients which was not defined in the literature before.