homovanillic acid


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ho·mo·va·nil·lic ac·id (HVA),

(hō'mō-vă-nil'ik as'id),
4-Hydroxy-3-methoxyphenylacetic acid; a phenol found in human urine; produced through the methylation of homoprotocatechuic acid on the meta-OH group. It is the principal urinary metabolite of dopa and dopamine.

homovanillic acid

/ho·mo·va·nil·lic ac·id/ (ho″mo-vah-nil´ik) a major terminal urinary metabolite, converted from dopa, dopamine, and norepinephrine.

homovanillic acid (HVA)

[hō′mōvənil′ik]
an acid that is produced by the normal metabolism of dopamine and that may occur at an elevated level in urine in association with tumors of the adrenal gland. Its normal accumulation in a 24-hour collection urine sample is 15 mg.

homovanillic acid

HVA Physiology A major dopamine metabolite used to synthesize epinephrine and norepinephrine and excreted in urine; HVA is usually measured with the major catecholamines and other catecholamine metabolites; HVA is ↑ in neuroblastoma and ganglioneuroma Ref range 0-15 mg/24 hr urine. See Hypertension, Pheochromocytoma.

ho·mo·va·nil·lic ac·id

(HVA) (hō'mō-vă-nil'ik as'id)
A phenol found in human urine; produced through the methylation of homoprotocatechuic acid on the meta-OH group.

ho·mo·va·nil·lic ac·id

(HVA) (hō'mō-vă-nil'ik as'id)
A phenol found in human urine.

homovanillic acid (hō´mōvənil´ik),

n an acid that is produced by normal metabolism of dopamine and may be elevated in the urine in association with tumors of the adrenal gland.
References in periodicals archive ?
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride (MPTP-HCI, CAS Number: 23007854), Dopamine Hydrochloride (DA-HCI, CAS Number: 62-31-7), and Homovanillic Acid (HVA, CAS Number: 306-08-1) were purchased from Sigma-Aldrich (U.
Homovanillic acid and 5-hydroxyindoleacetic acid cerebrospinal fluid levels.
1999) found higher levels of homovanillic acid in alcoholics compared with nonalcoholics, but other researchers (Petrakis et al.
Homovanillic Acid (HVA) -- Urinary HVA is the end metabolite of catecholamines, dopamine and urinary vanillylmandelic acid (VMA).
The end product is homovanillic acid (HVA, 4-hydroxy-3-methoxy-phenyl acetate), which is excreted via the cerebrospinal fluid (CSF).
Then, they allowed the hydrogen peroxide to react with homovanillic acid to form a fluorescent compound.
Dopamine (DA), 3,4-dihydroxyphenyl acetic acid (DOPAC), 3-metoxytyramine (3-MT), homovanillic acid (HVA), serotonin (5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) were all obtained from Sigma (St.
The major metabolites of these neurotransmitters that appear in human CSF are homovanillic acid (HVA) for dopamine, 5-hydroxyindoleacetic acid (5HIAA) for serotonin, and 3-methoxy, 4-hydroxyphenylglycol (MHPG) for norepinephrine; the concentrations of these are thought to reflect the overall turnover of the neurotransmitters within the CNS (4).
All four metals influenced the dopaminergic markers serum prolactin and urinary homovanillic acid, with complex interactions brought to light.
Laboratory values were significant for an elevated urine homovanillic acid (HVA)/creatinine ratio of 361, and a normal urine vanillylmandelic acid (VMA)/creatinine ratio.
17, from Alcaligenes species, 13 U/mg), m(1,3)-phenylenediamine, tyramine, ACh, choline (Ch), DA, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) were purchased from Sigma Chemicals.