homovanillic acid


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ho·mo·va·nil·lic ac·id (HVA),

(hō'mō-vă-nil'ik as'id),
4-Hydroxy-3-methoxyphenylacetic acid; a phenol found in human urine; produced through the methylation of homoprotocatechuic acid on the meta-OH group. It is the principal urinary metabolite of dopa and dopamine.
Farlex Partner Medical Dictionary © Farlex 2012

homovanillic acid

HVA Physiology A major dopamine metabolite used to synthesize epinephrine and norepinephrine and excreted in urine; HVA is usually measured with the major catecholamines and other catecholamine metabolites; HVA is ↑ in neuroblastoma and ganglioneuroma Ref range 0-15 mg/24 hr urine. See Hypertension, Pheochromocytoma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

ho·mo·va·nil·lic ac·id

(HVA) (hō'mō-vă-nil'ik as'id)
A phenol found in human urine; produced through the methylation of homoprotocatechuic acid on the meta-OH group.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

ho·mo·va·nil·lic ac·id

(HVA) (hō'mō-vă-nil'ik as'id)
A phenol found in human urine.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
There was only one compound, homovanillic acid (m/z 343), with statistically significant higher concentration in red fruits compared with both half-ripe and unripe fruits.
For this reason, the urine catecholamine metabolites, vanillylmandelic acid (VMA) and homovanillic acid (HVA), are often used to aid in the diagnosis of neuroblastoma.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride (MPTP-HCI, CAS Number: 23007854), Dopamine Hydrochloride (DA-HCI, CAS Number: 62-31-7), and Homovanillic Acid (HVA, CAS Number: 306-08-1) were purchased from Sigma-Aldrich (U.S.A.).
Although other metabolites, such as homovanillic acid and hydroxymethylmandelic acid have been used for diagnosis in the past, it is now agreed that MN, NMN, and 3MT have much better sensitivity and specificity.
Serum and urine catecholamine levels showed mild elevation of serum homovanillic acid (HVA) and urine vanillylmandelic acid (VMA).
Homovanillic acid and 5-hydroxyindole-acetic acid in the CSF of patients after a severe head injury: I.
Metoclopramide induces catalepsy and increases striatal homovanillic acid content in mice.
(2006) elegantly demonstrated that dopaminergic markers in the serum, namely prolactin and homovanillic acid, are affected in children exposed to cadmium, lead, mercury, and arsenic.
Other studies examining levels of the major byproduct of dopamine metabolism, homovanillic acid, also have had contradictory results.
Homovanillic Acid (HVA) -- Urinary HVA is the end metabolite of catecholamines, dopamine and urinary vanillylmandelic acid (VMA).
The end product is homovanillic acid (HVA, 4-hydroxy-3-methoxy-phenyl acetate), which is excreted via the cerebrospinal fluid (CSF).[7]