homoserine lactone

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ho·mo·ser·ine lac·tone

the cyclic ester (that is, the δ-lactone) of homoserine; formed by the reaction of cyanogen bromide on methionyl residues in peptides and proteins.

Farlex Partner Medical Dictionary © Farlex 2012

homoserine lactone

(hō″mō-sĕr′ēn lăk′tō″n)

A signaling chemical used by gram-negative bacteria in quorum sensing.

Mentioned in ?

quorum sensing

References in periodicals archive ?

Interaction of N-3-oxododecanoyl homoserine lactone with LasR protein of Pseudomonas aeruginosa: insights from molecular docking and dynamics simulations.

Biofilm production by clinical isolates of Pseudomonas aeruginosa and structural changes in LasR protein of isolates non biofilm-producing

cereus, these isolate had capability to degrade N-3-oxooctanoyl homoserine lactone and N-3-oxohexanoyl homoserine lactone rapidly.

Characterization of bacteria producing acyl homoserine lactone (AHL) lactonase from agricultural lands

The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclo-oxygenase-2 and prostaglandin E2 production in human lung fibroblasts: Implications for inflammation.

Immunization with 3-oxododecanoyl-L-homoserine lactone-r-PcrV conjugate enhances survival of mice against lethal burn infections caused by Pseudomonas aeruginosa

AHLs contain a common homoserine lactone ring, differing in their carbon lenght (4 to 18 carbons), degree of saturation, and the presence of C3 acyl chain modifications.

Identificacion, clonacion y actividad lactonasa de la proteina recombinante de N-acil homoserina lactonasa (AiiA) de Bacillus thuringiensis cepa 147-115-16

Gram-negative bacteria utilize the autoinducer-1 involving N-acyl homoserine lactone (AHL) and Gram-positive bacteria utilize the posttranslationally modified oligopeptide signaling molecules classified as autoinducer-2 [1, 4].

Pantoea sp. isolated from tropical fresh water exhibiting N-Acyl homoserine lactone production

Dijkstra, "The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket," Proceedings of the National Academy of Sciences of the United States of America, vol.

Genome sequencing of a mung bean plant growth promoting strain of P. aeruginosa with biocontrol ability

In Gram negative bacteria, the QS mediated pathogenesis occurs through N-acyl homoserine lactone (AHL) signal dependent mechanism (Smith and Iglewski 2003).

Antipathogenic potential of Rhizophora spp. against the quorum sensing mediated virulence factors production in drug resistant Pseudomonas aeruginosa

stewartii uses 3oxohexanoyl acyl carrier protein and SAdenosylL Methionine (SAM) as substrates to make 3oxohexanoyl homoserine lactone (AHL) autoinducers.

Optimization of HPLC coupled spectrophotometric assays for the determination of Esal AHL synthase kinetic coefficients

Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria.

Spices mix induces biofilm mode of growth in Escherichia coli

aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.

Novel complexes of molybdenum (VI) and oxovanadium (IV) with cycloheptanecarbohydroxamic acid (CPHA) and their therapeutic effect on some microorganisms

For example, red algae secrete halogenated furanones and enones that act as antagonists of acylated homoserine lactone signaling molecules present in biofilms.

Bacterial biofilms and HAIs

A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone compound, interacts with the lux box, modulating the activity of the promoter.