AHLs are highly conserved molecules having the common
homoserine lactone moiety but differ in the length and structure of the acyl side chain (3).
e peptide molecules which were produced by Gram positive bacteria and acyl
homoserine lactone (AHL) which were produced by Gram negative bacteria [15].
The Pseudomonas autoinducer N-(3-oxododecanoyl)
homoserine lactone induces cyclo-oxygenase-2 and prostaglandin E2 production in human lung fibroblasts: Implications for inflammation.
To date, the best known communication between bacteria occurs via the N-acyl
homoserine lactone (AHL): The enzyme Luxl produces signals that are recognised by the LuxR receptor, at which point the bacteria develop certain properties and modulate their behaviour towards one another.
AHLs contain a common
homoserine lactone ring, differing in their carbon lenght (4 to 18 carbons), degree of saturation, and the presence of C3 acyl chain modifications.
In Gram negative bacteria, the QS mediated pathogenesis occurs through N-acyl
homoserine lactone (AHL) signal dependent mechanism (Smith and Iglewski 2003).
stewartii uses 3oxohexanoyl acyl carrier protein and SAdenosylL Methionine (SAM) as substrates to make 3oxohexanoyl
homoserine lactone (AHL) autoinducers.
Plants secrete substances that mimic bacterial N-acyl
homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria.
aeruginosa autoinducer 3O-C12
homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
For example, red algae secrete halogenated furanones and enones that act as antagonists of acylated
homoserine lactone signaling molecules present in biofilms.
aeruginosa it appears that an acylated
homoserine lactone (acyl-HSL) is an important player in this type of cell to cell signaling [3].
A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated
homoserine lactone compound, interacts with the lux box, modulating the activity of the promoter.
