Interaction of N-3-oxododecanoyl homoserine lactone
with LasR protein of Pseudomonas aeruginosa: insights from molecular docking and dynamics simulations.
cereus, these isolate had capability to degrade N-3-oxooctanoyl homoserine lactone
and N-3-oxohexanoyl homoserine lactone
The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone
induces cyclo-oxygenase-2 and prostaglandin E2 production in human lung fibroblasts: Implications for inflammation.
AHLs contain a common homoserine lactone
ring, differing in their carbon lenght (4 to 18 carbons), degree of saturation, and the presence of C3 acyl chain modifications.
Gram-negative bacteria utilize the autoinducer-1 involving N-acyl homoserine lactone
(AHL) and Gram-positive bacteria utilize the posttranslationally modified oligopeptide signaling molecules classified as autoinducer-2 [1, 4].
Dijkstra, "The quorum-quenching N-acyl homoserine lactone
acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket," Proceedings of the National Academy of Sciences of the United States of America, vol.
In Gram negative bacteria, the QS mediated pathogenesis occurs through N-acyl homoserine lactone
(AHL) signal dependent mechanism (Smith and Iglewski 2003).
stewartii uses 3oxohexanoyl acyl carrier protein and SAdenosylL Methionine (SAM) as substrates to make 3oxohexanoyl homoserine lactone
Plants secrete substances that mimic bacterial N-acyl homoserine lactone
signal activities and affect population density-dependent behaviors in associated bacteria.
aeruginosa autoinducer 3O-C12 homoserine lactone
provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
For example, red algae secrete halogenated furanones and enones that act as antagonists of acylated homoserine lactone
signaling molecules present in biofilms.
A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone
compound, interacts with the lux box, modulating the activity of the promoter.