homoserine lactone


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ho·mo·ser·ine lac·tone

the cyclic ester (that is, the δ-lactone) of homoserine; formed by the reaction of cyanogen bromide on methionyl residues in peptides and proteins.
Farlex Partner Medical Dictionary © Farlex 2012

homoserine lactone

(hō″mō-sĕr′ēn lăk′tō″n)
A signaling chemical used by gram-negative bacteria in quorum sensing.
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
Interaction of N-3-oxododecanoyl homoserine lactone with LasR protein of Pseudomonas aeruginosa: insights from molecular docking and dynamics simulations.
cereus, these isolate had capability to degrade N-3-oxooctanoyl homoserine lactone and N-3-oxohexanoyl homoserine lactone rapidly.
The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclo-oxygenase-2 and prostaglandin E2 production in human lung fibroblasts: Implications for inflammation.
AHLs contain a common homoserine lactone ring, differing in their carbon lenght (4 to 18 carbons), degree of saturation, and the presence of C3 acyl chain modifications.
Gram-negative bacteria utilize the autoinducer-1 involving N-acyl homoserine lactone (AHL) and Gram-positive bacteria utilize the posttranslationally modified oligopeptide signaling molecules classified as autoinducer-2 [1, 4].
Dijkstra, "The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket," Proceedings of the National Academy of Sciences of the United States of America, vol.
In Gram negative bacteria, the QS mediated pathogenesis occurs through N-acyl homoserine lactone (AHL) signal dependent mechanism (Smith and Iglewski 2003).
stewartii uses 3oxohexanoyl acyl carrier protein and SAdenosylL Methionine (SAM) as substrates to make 3oxohexanoyl homoserine lactone (AHL) autoinducers.
Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria.
aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.
For example, red algae secrete halogenated furanones and enones that act as antagonists of acylated homoserine lactone signaling molecules present in biofilms.
A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone compound, interacts with the lux box, modulating the activity of the promoter.