homologous recombination


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homologous recombination

the exchange of corresponding stretches of DNA between two sister chromosomes.

ho·mol·o·gous re·com·bi·na·tion

(hŏ-mol'ŏ-gŭs rē-kom'bi-nā'shŭn)
The exchange of corresponding stretches of DNA between two sister chromosomes.
References in periodicals archive ?
Cui C, Song Y, Liu J, et al Gene targeting by TALEN-induced homologous recombination in goats directs production of p-lactoglobulinfree, high-human lactoferrin milk.
Van der Bosch M, Lohman PH, Pastnik A (2002) DNA double strand break repair by homologous recombination.
BRCA1 binds to RAD51 (9) which possesses a main role in Homologous Recombination (HR) by repairing endogenous and exogenous DNA double-strand breaks (11).
3] genes of the homologous recombination repair in colorectal cancer a case control study.
As the rDNA has a tandem repetitive structure, the repeat number is easily reduced by homologous recombination among the repeats.
A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q11.
Homologous recombination repair of DSBs is essential for making error-free genetic information from a homologous undamaged DNA molecule.
Homologous recombination is a type of genetic recombination where two molecules of DNA are exchanged.
In this work we performed bioinformatics analyses with the BCG_0092 sequence in order to identify major T cell epitopes and knocked out the BCG_0092 gene from BCG by homologous recombination.
It also was the first to demonstrate that correction of a defective gene in patient-derived cells via homologous recombination is possible.
Due to high level of identity, homologous recombination between amplicons causes deletions and duplications that explain 12% of all azoospermias and 6% of severe oligospermias.
5] BRCA2 is a tumour suppressor protein involved in the repair of DNA double-strand breaks via homologous recombination (HR).