homologous recombination


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homologous recombination

the exchange of corresponding stretches of DNA between two sister chromosomes.

ho·mol·o·gous re·com·bi·na·tion

(hŏ-mol'ŏ-gŭs rē-kom'bi-nā'shŭn)
The exchange of corresponding stretches of DNA between two sister chromosomes.
References in periodicals archive ?
constructed a knock-in vector containing the human tissue plasminogen activator mutant gene, and somatic cells were successfully transfected with this vector via homologous recombination.
Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination.
Targeting homologous recombination using imatinib results in enhanced tumour cell chemosensitivity and radiosensitivity.
Over expression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation.
Earlier it was found that a protein molecule named Srs2 regulates homologous recombination by counteracting the work of another protein, Rad51.
5) Nonstandard abbreviations: A-V, atrioventricular; FISH, fluorescence in situ hybridization; aCGH, array comparative genomic hybridization; BAC, bacterial artificial chromosome; ST-FISH, subtelomere FISH; MLPA, multiplex ligation and probe amplification; NAHR, nonallelic homologous recombination.
Topics include discussions of research in the following areas: an introduction to gene mapping, phylogenetics in the face of lteral gene transfers, the role of recombination in the post-genomic era, genomic DNA rearrangement in the brain, natural genetic recombination of pathogens, the extent and limits of genetic recombination, and homologous recombination and innocuous intron elimination.
Cellectis holds exclusive rights to 148 patents and patent applications providing the company with a strong position in the field of homologous recombination (3 issued US patents) and meganucleases and uses thereof (18 issued US patents) both naturally-occurring and with engineered specificity.
Yale University (New Haven, CT) has patented a yeast-bacteria shuttle vector that can be used to clone large regions of DNA by homologous recombination.
Its more crucial method, known as homologous recombination, uses a protein called RecA to patch double-strand breaks.
Tumor cells with BRCA1 or BRCA2 mutations have a deficiency in the repair of DNA double strand breaks (DSBs) by the homologous recombination (HR) pathway.