The heat shock protein 70 family: Highly homologous proteins
with overlapping and distinct functions.
When a homologous protein
with a recognized structure is identified, it can be used as a template to model the 3D structure for the query protein (Rychlewskiet al., 1998), because homologous proteins
usually have quite similar 3D structures (Kinch and Grishin, 2002).
In the 3-dimensional helical folding of the homologous proteins
, IEMDT shows twenty-one [alpha]-helices, twelve [beta] strands, and two n, while SPLTB and STT have two [alpha]-helices and five [beta] strands (Figure 3).
For phylogeny four closest homologous proteins
of TGF-[beta] superfamily were selected i.e.
The RAS proto-oncogenes (ERAS, KRAS, and NRAS) encode HRAS, KRAS 4A, KRAS 4B, and NRAS, 4 distinct but closely related and highly homologous proteins
. These enzymes, located on the inner surface of the cell membrane, represent GDP/GTP-regulated switches that convey extra-cellular signals and play a central role in signal transduction, regulating cell proliferation, and apoptotic cell death.
We performed pairwise genome-wide comparative analysis by comparing homologous proteins
from pairs of Bartonella species.
Number enterica serovar Poona Total number of proteins 4906 Duplicates (>60% identity) in CD-HIT 154 Nonparalogs 4752 Nonhuman homologous proteins
3664 (E-value [10.sup.-4]) Essential protein in DEG (E-value [10.sup.-100]) 198 Pathways unique to Salmonella enterica 14 subsp.
Secondly, GO annotation information of the homologous proteins
of apoptosis proteins is used to represent proteins, and a GO subspace is constructed by selecting a set of relevant GO terms from all the GO terms in GO database to avoid the curse of dimensionality.
Antibodies formed to species-specific protein components typically bind only to the proteins particular to that species, but homologous proteins
(with similar structures) may also exist in related or unrelated species.
in 1996, ET method enables the identification of conservation pattern within homologous proteins
by comparing both the amino acid sequence and protein crystal structure information .
The same reaction also occurs during heme [d.sub.1] biosynthesis in denitrifying bacteria where it is catalyzed by the homologous proteins
NirD, NirL, NirG, and NirH .