homologous desensitization

ho·mol·o·gous de·sen·si·tiz·a·tion

loss of sensitivity only to the class of agonist used to desensitize the tissue.
References in periodicals archive ?
Conclusion: Taken together, these results indicate that [alpha]-hederin acts as an indirect GRK2 inhibitor leading to a reduced homologous desensitization of [[beta].
2]AR is regulated at conditions of high agonist concentrations by heterologous and homologous desensitization and subsequently by internalization.
In normal individuals, ghrelin is partially resistant to a previous administration of GHRP-6 and to the ensuing GH rise for which two types of cellular responses have been proposed: the homologous desensitization effects and the cross-talk observed between the GHRH receptor and the GHS receptor.
Ghrelin-induced GH secretion in normal subjects is partially resistant to homologous desensitization by GH-releasing peptide-6.
Homologous desensitization of [beta]-adrenergic receptor coupled adenylate cyclase.