homogentisic acid


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homogentisic acid

 [ho″mo-jen-tis´ik]
2,5-dihydroxyphenyl acetic acid, an intermediate product in the metabolism of tyrosine and phenylalanine, excreted in the urine in the inborn error of metabolism known as phenylketonuria.

ho·mo·gen·tis·ic ac·id

(hō'mō-jen-tis'ik as'id),
Glycosuric acid; (2,5-dihydroxyphenyl)acetic acid; an intermediate in l-phenylalanine and l-tyrosine catabolism; if made alkaline, it oxidizes rapidly in air to a quinone that polymerizes to a melaninlike material; elevated levels are observed in patients with alcaptonuria.
Synonym(s): alcapton, alkapton

homogentisic acid

(hō′mō-jĕn-tĭz′ĭk)
n.
An intermediate of the metabolic breakdown of tyrosine and phenylalanine; it occurs in the urine in cases of alkaptonuria.

ho·mo·gen·tis·ic ac·id

(hō'mō-jen-tis'ik as'id)
An intermediate in l-phenylalanine and l-tyrosine catabolism; if made alkaline, it oxidizes rapidly in air to a quinone that polymerizes to a melaninlike material; elevated levels are observed in individuals having alcaptonuria.
Synonym(s): alcapton, alkapton.

homogentisic acid

see GARROD, A.
References in periodicals archive ?
Therapeutic method include mega dose of vitamin C (upto 1 gm /day) for the degradation of homogentisic acid. Antiresorptive drugs such as alendronate and ibandronic acid are not proven to benefit in ochronotic spine with osteopenia.
Gallic acid, pyrogallol, homogentisic acid, protocatechuic acid, (+) catechin, chlorogenic acid, caffeic acid, vanillin, ferulic acid, naringin, resveratrol, naringenin, hesperetin, formononetin and biochanin-A were used as standard for the detection of phenolic compounds from the fruiting bodies of P.
Ochronosis (alkaptonuria) or black urine disease is an autosomal recessive metabolic disease and occurs due to homogentisic acid oxidase (HGAO) enzyme deficiency.
Patients do not have enough of the enzyme homogentisic acid oxidase, which causes acid to build up in the body.
Specifically, the 15 disorders found in the abnormal urine samples were characterized by 34 unique or abnormally abundant metabolites (e.g., homogentisic acid, glycerol, glutaric acid, and others).
Ochronosis (alkaptonuria) is an autosomal recessive disorder characterized by increased urinary excretion of homogentisic acid. The gene responsible for the disorder has been localized to chromosome 3q.[1] The disorder is caused by an enzyme deficiency that results in an inability to catabolize homogentisic acid, an intermediary component in the metabolism of tyrosine and phenylalanine.