homogentisate 1,2-dioxygenase

ho·mo·gen·tis·ate 1,2-di·ox·y·gen·ase

(hō'mō-jen'tis-āt dī-oks'i-jen-ās),

An iron-containing enzyme that catalyzes the oxidative cleavage of the benzene ring in homogentisic acid by O₂, forming 4-maleylacetoacetate; an absence or deficiency of this enzyme will result in alcaptonuria.

Synonym(s): homogentisic acid oxidase