homeobox genes


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homeobox genes

A highly CONSERVED family of genes, found in a large range of different species, including insects. Homeobox genes are expressed early in embryonic development and are the determinants of body shape. These genes divide the early embryo into fields of cells each with the potentiality to develop into a particular part such as an arm, leg, tissue or organ. This is the key to the long-unexplained problem of how bodily configuration is determined by genetics. Mutations in homeobox genes cause severe bodily defects such as PHOCOMELIA.
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Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development.
Development of Liver and Pancreas
Genes of the NK2 class have a distinctive homeobox and encode proteins that have a tyrosine at homeodomain position 54, and the Tlx family of homeobox genes is distinguished by a Thr in position 47 of the homeodomain.
Hox, Parahox, EHGbox, and NK genes in bivalve molluscs: evolutionary implications
Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5.
Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis
The fact that each of the fields expresses different combinations of patterning homeobox genes supports this theory
Homeobox genes--the mirror of tooth development
1) is a homeobox gene with mutations that effect second premolars and third molars with an association for cleft lip and/or palate and Witkop syndrome (Zhang et al.
Molecular factors resulting in tooth agenesis and contemporary approaches for regeneration: a review
Expression pattern of KN-1 type tobacco homeobox genes.
Leaf development, metamorphic heteroblasty and heterophylly in Berberis s. l
Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development.
Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism/Atriyal izomerizmli hastalarda NKX2-5 ve HAND1 genlerindeki dizi farkliliklari
Members of the Antennapedia class of homeobox genes, known as Hox genes, are believed to be pivotal in regulating vertebrate craniofacial development and controlling morphogenesis and the growth of the proximal-distal axis.
Congenital familial bilateral branchial tracts: a rare case
Missense mutations in R31 have been found in the human homeobox genes PITX2, MSXI, MSX2, LMX1B, and HOXD13 and are associated with 5 different developmental diseases: iridogoniodysgenesis syndrome, tooth agenesis, enlarged parietal foramina, nail-patella syndrome, and several digital anomalies, respectively (18, 19).
Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome
Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.
Genes underlying familial hypodontia: a review and discussion of the role of dental hygienists in future research
Although researchers know that alcohol can affect the expression of some genes, it is uncertain whether these include homeobox genes.
Prenatal Exposure to Alcohol
Such products might be extracellular signaling molecules, such as growth factors or differentiation signals, but also transcriptional regulators, for example, a retinoic acid receptor acting on homeobox genes in a developing vertebrate limb.
Does evolutionary plasticity evolve?

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