homeobox genes


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homeobox genes

A highly CONSERVED family of genes, found in a large range of different species, including insects. Homeobox genes are expressed early in embryonic development and are the determinants of body shape. These genes divide the early embryo into fields of cells each with the potentiality to develop into a particular part such as an arm, leg, tissue or organ. This is the key to the long-unexplained problem of how bodily configuration is determined by genetics. Mutations in homeobox genes cause severe bodily defects such as PHOCOMELIA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Cappechi plans to disrupt several other of the 40 or so homeobox genes in mice in hopes of elucidating their function.
Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.
HOM/HOX homeobox genes are present in hydra (Chlorohydra viridissima) and are differentially expressed during regeneration.
elegans LIM homeobox genes leads to another interesting point: the expression of most, if not all of these genes is maintained in neural tissues throughout adulthood.
Identification of a retinoic acid responsive enhancer 3[prime] of the murine homeobox gene Hox 1.6.
We have chosen to study homeobox genes in the Anthozoa that we might better understand the ancestral function of these genes in the Cnidaria and in the Eumetazoa.
Machida, "The ASYMMETRICLEAVES2 gene of Arabidopsis thaliana regulates formation of a symmetric lamina, establishment of venation and repression of meristem-related homeobox genes in leaves," Development, vol.
Bechi et al., "Expression of HOX homeobox genes in the adult human colonic mucosa (and colorectal cancer?)," International Journal of Molecular Medicine, vol.
Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbxl, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression.
The sonic hedgehog, homeobox gene Pdx1, and Notch signaling systems are effective in the development of the pancreas (43, 44).
Boncinelli, "Homeobox genes and cancer," Experimental Cell Research, vol.
Homeobox genes are involved in body plan formation and in the regulation of many developmental processes in bilateria.