homeobox


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ho·me·o·box

(hō'mē-ō-boks),
A highly conserved DNA sequence of about 180 base pairs near the 3' end of specific homeotic genes; it encodes a DNA-binding domain that allows the homeobox proteins to bind to and regulate gene expression in development.
Synonym(s): homeodomain

homeobox

(hō′mē-ə-bŏks′)
n.
A sequence of DNA encoding a protein structure that binds to specific parts of DNA and affects transcription of DNA into RNA.

homeobox

a conserved DNA motif of about 180bp encoding a protein domain (approximately 60 amino acids) that binds to DNA. The homeobox is a characteristic of HOMEOTIC GENES and is found in most EUKARYOTES.
References in periodicals archive ?
Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals.
A dominant mutation in the maize homeobox gene, Knotted-1, causes its ectopic expression in leaf cells with altered fates.
(39.) Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RR Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
Retinoic acid likely acts in this capacity by binding to receptors that regulate the expression of homeobox genes.
Hake's finding, reported in a cover article of the international scientific journal Nature in 1991, added plants to the list of organism--fruit flies, beetles, worms, mice, frogs, and humans, for instance--already known to contain influential homeobox regions.
A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.
En cuanto al gen Homeobox Arx, se dice que tiene una accion indirecta en la diferenciacion de las celulas intersticiales, ya que tiene una expresion mas elevada en las celulas mioides.
Pit-Oct-Unc Domain, Class 1, Transcription Factor 1 (Pit1) is a member of the tissue-specic POU homeobox transcription factor family that is found in all mammals.
The first article uses 7 challenging yet representative examples to comprehensively review some diagnostic strategies and algorithms; to update many recently described diagnostic markers, such as von Hippel-Lindau tumor suppressor gene protein (pVHL), paired box gene (PAX) 8, ETS-related gene (ERG), sal-like protein 4 (SALL4), sex-determining region Y box (SOX) 10, NK3 homeobox 1 (NKX3.1), discovered on GIST1 (DOG1), and Merkel cell polyomavirus (McPyV); and to refine the diagnostic IHC panels frequently used in daily practice.
The short stature homeobox (SHOX) gene is located in the pseudo-autosomal regions of the short arms of the X and Y chromosomes.
The molecular genetic research showed the association between X-linked hearing loss and mutations in POU3F4 .[sup][3] This gene belongs to a superfamily of POU domain transcription factors (transcription factor 4 of the POU domain, Class III), which encodes transcription factor with bipartite DNA-binding domains, a 75-amino acid POU-specific domain that is linked by 17 amino acids to a 63-amino acid homeobox domain.
To date, two major genes, forkhead box C1 (FOXC1) on chromosome 6p25 and pituitary homeobox 2 (PITX2) on chromosome 4q25, have been demonstrated to cause ARS.