holoenzyme


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Related to holoenzyme: apoenzyme

holoenzyme

 [hol″o-en´zīm]
the active compound formed by combination of a coenzyme and an apoenzyme.

hol·o·en·zyme

(hol'ō-en'zīm),
A complete enzyme, that is, apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

holoenzyme

/holo·en·zyme/ (-en´zīm) the active compound formed by combination of a coenzyme and an apoenzyme.

holoenzyme

(hŏl′ō-ĕn′zīm′, hō′lō-)
n.
An active, complex enzyme consisting of an apoenzyme and a coenzyme.

holoenzyme

[hol′ō·en′zīm]
Etymology: Gk, holos + en, in, zymos, ferment
a complete enzyme-cofactor complex that gives rise to full catalytic activity.

hol·o·en·zyme

(hol'ō-en'zīm)
A complete enzyme, i.e., apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

holoenzyme

A complete enzyme that includes its prosthetic coenzyme. An enzyme without its coenzyme is called an apoenzyme.

holoenzyme

an entire conjugated enzyme consisting of a protein component (an apoenzyme) and a nonprotein component (a coenzyme or an activator).

holoenzyme

an enzyme which contains several different subunits and retains some activity even when one or more of the subunits is missing.
References in periodicals archive ?
Another reversible dissociation mechanism regulated by the C subunit underlies the separation of the holoenzyme V1V0 into V1 and V0 subcomplexes, which occurs through the binding of the C subunit and F-actin proximal to the basement membrane of epithelial cells.
Several domains of pol [gamma]B interact with pol [gamma]A as shown by electron microscopy and the recent pol [gamma] holoenzyme crystal structure.
Undoubtedly the regulation of V-ATPases is a highly complex process as it requires the expression of genes encoding the various subunits, assembly and targeting of the V-ATPase holoenzyme to functionally diverse subcellular compartments, and modulation of activity in response to a host of developmental, physiological and environmental stimuli.
The ultramutated phenotype is attributed to somatic mutations in the exonuclease domain of POLE, which encodes the catalytic and proofreading subunit of the polymerase e holoenzyme that catalyzes leading-strand synthesis during DNA replication and regulates cell cycle progression, chromatin remodeling, and DNA repair (59).
14),15),17) The set of promoters recognized by RNA polymerase holoenzyme is determined by the species of associated < factor.
Although, the mechanism by which the [alpha]-subunit regulates amounts of the holoenzyme is currently unknown, it would be in conjunction with changes in the rate of collagen synthesis.
However, the binding activity of cAMP to the holoenzyme was not inhibited with SGL-II.
coli K12 strain (AVB100) containing a chromosomal copy of the biotin holoenzyme synthetase (birA) gene under the control of an L-arabinose-inducible promoter (Avidity Inc.
Of equal interest is that, if one coats Protein A Sepharose (PAS) beads with a specific monoclonal antibody to the Ku protein, Ku 162, and then uses these beads to isolate the Ku proteins from the cytoplasmic extracts of fertilized eggs, the beads bind the holoenzyme, and in this bound form the enzyme is active in the absence of (ds)DNA.
Koleske have evidence that, in yeast, several SRB proteins chair a committee - called a holoenzyme - that includes RNA polymerase and several other substances important for reading the genetic code.
Hydroxylamine is a carbonyl-specific reagent that reversibly dissociates PLP from the holoenzyme.