holoenzyme


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Related to holoenzyme: apoenzyme

holoenzyme

 [hol″o-en´zīm]
the active compound formed by combination of a coenzyme and an apoenzyme.

hol·o·en·zyme

(hol'ō-en'zīm),
A complete enzyme, that is, apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

holoenzyme

(hŏl′ō-ĕn′zīm′, hō′lō-)
n.
An active, complex enzyme consisting of an apoenzyme and a coenzyme.

hol·o·en·zyme

(hol'ō-en'zīm)
A complete enzyme, i.e., apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

holoenzyme

A complete enzyme that includes its prosthetic coenzyme. An enzyme without its coenzyme is called an apoenzyme.

holoenzyme

an entire conjugated enzyme consisting of a protein component (an apoenzyme) and a nonprotein component (a coenzyme or an activator).
References in periodicals archive ?
Through analysis and observations of these seven native states, the authors conclude that these seven states are on the pathway of substrate processing by the holoenzyme.
For this, we purified recombinant Med6p having ts-2 mutation or internal deletion mutations and examined their capabilities in restoring the transcriptional defects of Pol II holoenzyme caused by med6 ts-2 mutation [20].
Conceptually, one might expect that a similar number of activated [T.sup.287] autophosphorylated subunits ([T.sup.286] in alpha isoform) would produce similar levels of substrate phosphorylation within the PSD regardless of whether the catalytic subunits are within a holoenzyme or monomeric.
To date, over 30 gene products have been identified that are solely involved in the biogenesis of the holoenzyme [83].
Kopperud et al., "Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition," Journal of Biological Chemistry, vol.
There was a non-significant change observed in holoenzyme activity after 3.5hrs (acute) treatment in contrast there was significant decrease by 32% (pless than 0.01) after 7 days treatment.
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
Romanowski et al., "MCM proteins are associated with RNA polymerase II holoenzyme," Molecular and Cellular Biology, vol.
More recent work indicates that the induction of cyclin D-CDK complexes results in the redistribution of CDK inhibitor p27Kip1 from cyclin E-CDK2 complexes to cyclin D-CDK4y6 complexes, thereby triggering the kinase activity of cyclin E-CDK2 holoenzyme [13].
Similarly, the 64 genes of the red line in Q2 are related to the chromatin, WINAC complex, or DNA-directed RNA polymerase II, holoenzyme. The adding dose can reverse the gene expression pattern from downregulation to upregulation.
Protein phosphatase 2A (PP2A) is an important phosphatase which consists of a holoenzyme composed of the structural A and catalytic C subunits and a regulatory B subunit [1-3].
Schatz, "A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation," Protein Science, vol.