holoenzyme


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Related to holoenzyme: apoenzyme

holoenzyme

 [hol″o-en´zīm]
the active compound formed by combination of a coenzyme and an apoenzyme.

hol·o·en·zyme

(hol'ō-en'zīm),
A complete enzyme, that is, apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

holoenzyme

/holo·en·zyme/ (-en´zīm) the active compound formed by combination of a coenzyme and an apoenzyme.

holoenzyme

(hŏl′ō-ĕn′zīm′, hō′lō-)
n.
An active, complex enzyme consisting of an apoenzyme and a coenzyme.

holoenzyme

[hol′ō·en′zīm]
Etymology: Gk, holos + en, in, zymos, ferment
a complete enzyme-cofactor complex that gives rise to full catalytic activity.

hol·o·en·zyme

(hol'ō-en'zīm)
A complete enzyme, i.e., apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

holoenzyme

A complete enzyme that includes its prosthetic coenzyme. An enzyme without its coenzyme is called an apoenzyme.

holoenzyme

an entire conjugated enzyme consisting of a protein component (an apoenzyme) and a nonprotein component (a coenzyme or an activator).

holoenzyme

an enzyme which contains several different subunits and retains some activity even when one or more of the subunits is missing.
References in periodicals archive ?
Several domains of pol [gamma]B interact with pol [gamma]A as shown by electron microscopy and the recent pol [gamma] holoenzyme crystal structure.
Undoubtedly the regulation of V-ATPases is a highly complex process as it requires the expression of genes encoding the various subunits, assembly and targeting of the V-ATPase holoenzyme to functionally diverse subcellular compartments, and modulation of activity in response to a host of developmental, physiological and environmental stimuli.
In this respect, it is considered that the [alpha]-subunit of P4H plays an important role in activating the P4H holoenzyme.
The ultramutated phenotype is attributed to somatic mutations in the exonuclease domain of POLE, which encodes the catalytic and proofreading subunit of the polymerase e holoenzyme that catalyzes leading-strand synthesis during DNA replication and regulates cell cycle progression, chromatin remodeling, and DNA repair (59).
coli K12 strain (AVB100) containing a chromosomal copy of the biotin holoenzyme synthetase (birA) gene under the control of an L-arabinose-inducible promoter (Avidity Inc.
Koleske have evidence that, in yeast, several SRB proteins chair a committee - called a holoenzyme - that includes RNA polymerase and several other substances important for reading the genetic code.
Hydroxylamine is a carbonyl-specific reagent that reversibly dissociates PLP from the holoenzyme.
The NKA holoenzyme is composed of two subunits ([alpha] and [beta]), each of which has at least three genetically distinct isoforms (7-9).
The released cofactor FAD binds to apo n-amino acid oxidase, and the resulting active holoenzyme catalyzes the oxidation of n-proline to produce [H.
16,17) The eukaryotic cell cycle is driven forward by cyclins, which form holoenzymes together with their cyclin-dependent kinase (CDK) partners.