Held

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Held

(held),
Hans, German anatomist, 1866-1942. See: Held bundle, Held decussation.

ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in classic literature ?
"Wherefore should I hold, good fellow?" said the stranger in soft and gentle voice.
"I have said all," quoth Robin, "and now, if thou wilt give me thy purse, I will let thee go thy way without let or hindrance so soon as I shall see what it may hold. I will take none from thee if thou hast but little."
"Thus: Once in every year, on the first day of the new moon of the summer season, Jikiza holds a meeting of the headmen.
But suddenly Umslopogaas stood up, looking at him over the top of his war shield, and crying, "Here is one, O Jikiza, who will do battle with you for the axe Groan-Maker and for the chieftainship that is to him who holds the axe."
For they advised him so, to the end that no other should hold royal sway over the eternal gods in place of Zeus; for very wise children were destined to be born of her, first the maiden bright-eyed Tritogeneia, equal to her father in strength and in wise understanding; but afterwards she was to bear a son of overbearing spirit, king of gods and men.
There Gyes and Cottus and great-souled Obriareus live, trusty warders of Zeus who holds the aegis.
At the same time, he hugged his shuddering body in both his arms - clasping himself, as if to hold himself together - and limped towards the low church wall.
Well, we had the boat about ready to be launched, when this man sang out pretty shrill: "For God's sake, hold on!" We knew by his tone that it was something more than ordinary; and sure enough, there followed a sea so huge that it lifted the brig right up and canted her over on her beam.
It was the spare yard I had got hold of, and I was amazed to see how far I had travelled from the brig.
I pray you not to hold him back, for it would be an evil thing if all the stout lads were there and the leader a-missing.
So moved was the young clerk by these mute appeals, that he came forth from the trees and crossed the meadow, uncertain what to do, and yet loth to hold back from one who might need his aid.
Veiling his clear-cut, lean face in a thin layer of a hard, high cloud, I have seen him, like a wizened robber sheik of the sea, hold up large caravans of ships to the number of three hundred or more at the very gates of the English Channel.