Shatkin, "Methyl labeling of HeLa cell hnRNA
: a comparison with mRNA," Cell, vol.
For example, studies on snRNAs have shown that their primary function is the processing of pre-mRNAs (heterogeneous nuclear RNA or hnRNA
) in the nucleus.
However, they were soon given the short nickname of "cap" in a study to confirm the precursor-product relationship between heterogeneous nuclear RNA (hnRNA) and cytoplasmic mRNA.
For example, I identified caps in mRNAs and precursor hnRNA of HeLa cells.
(30) found that adding 5'-cap structures occurs early in HeLa hnRNA synthesis.
(1976) Methyl labeling of HeLa cell hnRNA: a comparison with mRNA.
Effects og hnRNA
and protein synthesis inhibition on chromosome condensation and H-1 and MAP kinase activities during in vitro maturation of porcine oocyte.
Has a high ribonucleoprotein A/B affinity for G-rich and U-rich regions of hnRNA
Heterogeneous nuclear Binds with high affinity to RNA ribonucleoprotein DO molecules that contain AU-rich elements (AREs) found within the 3;-UTR of many proto oncogenes and cytokine mRNAs Heterogeneous nuclear This protein is a component of the ribonucleoprotein H heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.
Transkripsiyon sirasinda olusan heteronukleer RNA (hnRNA
) RNA islenmesi surecinden gecerek "mesajci RNA"yi (mRNA) olusturur.
The first step occurs within the nucleus and involves synthesis of the primary RNA transcript or heterogeneous nuclear RNA (hnRNA
) [ILLUSTRATION FOR FIGURE 3 OMITTED].
Indeed, both FTO and HNRNPK are part of the hnRNA metabolism.
m6A is the most prevalent internal modification in hnRNAs in higher eukaryotes and widely conserved among eukaryotic species [26, 27].