Gas gangrene starts with a traumatic lesion, commonly vaccination, parturition, neutering, docking and blood extraction, followed by the contamination of the wounds by one or more of the histotoxic
clostridia, including C.
They cover the pathogenic clostridia, toxins produced by the pathogenic clostridia, clostridial infections of the gastrointestinal system, clostridial histotoxic
infections, and clostridial neurotoxic infections.
Clostridium perfringens is one of the most important food-borne pathogen of humans and animals causing both histotoxic
diseases and intestinal infections (4-7).
On the other hand, the free fatty acid theory proposes that excessive mobilization of free fatty acids leads to severe vasculitis that is secondary to its histotoxic
The alpha toxin is reported as hemolytic, necrotic and histotoxic
(Quinn et al.
This toxin is reported as hemolytic necrotic and histotoxic
(Quinn et al.
The reasons for such oxygen deprivation to the brain vary and include cardiac arrest, inadequate blood flow, histotoxic
causes like poisoning and trauma to brain and body as in strangulation and can occur at high altitudes in the absence of oxygen and low blood flow.
Hypoxia: This occurs when the utilization of oxygen by the body tissues is interfered with.
Clostridial toxins involved in human enteric and histotoxic
Cyanides and hydrogen sulfide act as tissue poisons, shutting down cellular metabolism (producing so-called histotoxic
hypoxia is a type of poisoning that interferes with the body's ability to use oxygen; cyanide poisoning is one well-known example.
Hypoxia exists in four different types: hypoxic, anemic, stagnant, and histotoxic