It is an acute, endogenous/soil-borne infection caused by Clostridium chauvoei, a Gram positive, motile,
histotoxic, and sporulating anaerobic bacterial species (USEH et al., 2006a).
"
Histotoxic hypoxia" is the medical term associated with the disorientating disorder which can put pilots' lives at risk, as well as those of civilians on the ground below.
They cover the pathogenic clostridia, toxins produced by the pathogenic clostridia, clostridial infections of the gastrointestinal system, clostridial
histotoxic infections, and clostridial neurotoxic infections.
Clostridium perfringens is one of the most important food-borne pathogen of humans and animals causing both
histotoxic diseases and intestinal infections (4-7).
On the other hand, the free fatty acid theory proposes that excessive mobilization of free fatty acids leads to severe vasculitis that is secondary to its
histotoxic effects.[sup][2] CFE can be present without pulmonary effects; potentially due to the fact that smaller globules may traverse the pulmonary microvasculature and reach the systemic circulation; alternatively, CFE may be caused by fat globules via the patent foramen ovale.[sup][3] Three patients went into a coma shortly after the fracture and remained comatose at the 3-month follow-up.
The alpha toxin is reported as hemolytic, necrotic and
histotoxic (Quinn et al., 2005).
This toxin is reported as hemolytic necrotic and
histotoxic (Quinn et al.
Neutrophils are essential to contain and clear infectious agents, but due to their indiscriminate
histotoxic potential they are tightly regulated by a mechanism that involves "priming" before full activation [127].
The reasons for such oxygen deprivation to the brain vary and include cardiac arrest, inadequate blood flow,
histotoxic causes like poisoning and trauma to brain and body as in strangulation and can occur at high altitudes in the absence of oxygen and low blood flow.
Histotoxic Hypoxia: This occurs when the utilization of oxygen by the body tissues is interfered with.
Clostridial toxins involved in human enteric and
histotoxic infections.
Clostridium chauvoei, the etiologic agent of blackleg, is a grampositive, motile,
histotoxic, and sporulating anaerobic bacterium (QUINN et al., 2011).
