historical control

A control group that is chosen from a group of patients who were observed at some time in the past or for whom data are available through records. Historical controls are used for comparison with subjects being treated or assessed concurrently
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

historical control

Epidemiology A control group that is chosen from a group of patients who were observed at some time in the past or for whom data are available through records; HCs are used for comparison with subjects being treated concurrently. See Control.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
If Resten-MP can significantly reduce late lumen loss at six months compared to the historical control, there is every confidence that pivotal studies would demonstrate the therapeutic value of the drug."
The trial design assumes 80% power to detect the historical control of a 20% adverse event rate per IGIV infusion.
Patients were followed for 24 months post treatment and compared with a historical control cohort of 26 patients with ADA-SCID who underwent hematopoietic stem cell transplant, or HSCT, 12 from matched related donors, or MRD, and 14 without a MRD.
Nurses' notes were reviewed for the 6-month preassault period and a 6-month historical control period during which the patient had been clinically stable.
This small sample size is inadequate to determine a normal AGD value, and there are no historical control data for AGD in male human infants using a definition of AGD comparable to the one used by Swan et al.
Advanced pancreatic cancer patients treated with Tumor Treating Fields plus gemcitabine experienced a median progression free survival of 8.3 months (95% CI 4.3, 10.3) and a median overall survival of 14.9 months (95% CI 6.2, NA), compared to 3.7 months and 6.7 months, respectively, in the gemcitabine historical control.
The study's primary endpoint is to demonstrate an ORR benefit compared to historical control of 12-15%.
* Matched historical control data--The nine month results show a meaningful improvement in the motor function recovery in the AIS -A patients receiving 10 million AST-OPC1 cells compared to a historical control group of 62 closely matched patients from the EMSCI database.
* Matched historical control data - The nine month results show a meaningful improvement in the motor function recovery in the AIS -A patients receiving 10 million AST-OPC1 cells compared to a historical control group of 62 closely matched patients from the EMSCI database.
Wave's application for the CID pilot program includes a plan to leverage DMD historical control data to augment the placebo arm of the suvodirsen Phase 2/3 clinical trial, among other design elements.
Titled "A Prospective, Open-Label, Multicenter Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of Evolve PlasmaCap IG in Adults and Children with Primary Immune Deficiency Diseases," the study will determine, based on historical control data, how PlasmaCap IG compares with other 10% IVIG products currently licensed in the US and Canada for the treatment of patients with PIDD.

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