histones


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histones

Strongly alkaline proteins associated with DNA. Histones may be released into the blood and appear in the urine when tissue breaks down in wasting illnesses.
References in periodicals archive ?
Adaptive evolution of the histone fold domain in centromeric histones.
So it makes sense that histone methylation is largely used to silence master genes that may be needed at multiple points during development, while DNA methylation is mostly used to switch off genes at later stages, when cells have already been tailored to specific functions, and those genes are less likely to be needed again.
Ethanol-induced alterations in SAMe levels can affect the methylation of histones or DNA, which in turn can modify gene expression, thereby contributing to liver injury (Lu and Mato 2012).
These cup-shaped macromolecules bind preferentially to certain histone code elements.
Eukaryotic cells have evolved multiple mechanisms to maintain histone abundance at appropriate levels," said study lead author Nupam P.
Histone phosphorylation and chromatin structure during mitosis in Chinese hamster cells.
Methylated cytosines of silenced promoters bind to methyl-CpG-binding domain proteins (MBDs) in a complex that also includes HDACs, which remove acetyl groups from histones and transform the heterochromatin into a closed, transcriptionally inactive status (5, 6).
The fundamental unit of chromatin is the nucleosome body that is an octameric assembly of basic proteins, the histones wrapped around by 146 bp of DNA.
Phosphorylation and methylation of histones may either turn genes offor on, depending on where the chemicals are pinned to the histone tail.
Histones, which exist in numerous variants, regulate gene expression, with the level of gene expression depending on the modifications that the histones undergo.
In order to investigate the role of histone acetylation in establishing an infection by simian virus 40 (SV40), we have analyzed formalin fixed and unfixed SV40 chromosomes obtained 30 minutes and 3 hours post-infection for the presence of tetraacetylated histone H4 and di-acetylated histone H3 using a combination of chromatin immunoprecipitation (ChIP) techniques including quantitative ChIP assays with competitive PCR, depletion analyses, and competitive ChIP analysis.
The present Competitive Intelligence report about HDAC Inhibitors provides a competitor evaluation in the field of novel molecular entities inhibiting histone deacetylase for treatment of cancer and other diseases as of July 2011.

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