histones


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histones

Strongly alkaline proteins associated with DNA. Histones may be released into the blood and appear in the urine when tissue breaks down in wasting illnesses.
References in periodicals archive ?
The researchers harvested satellite cells from both healthy and injured muscle tissue of young mice and from healthy tissue of old mice; extracted these cells' DNA with the histone coatings intact; and used tagged antibodies targeting the different kinds of marks to find which spots on those histones were flagged with either "stop" or "go" signals.
So it makes sense that histone methylation is largely used to silence master genes that may be needed at multiple points during development, while DNA methylation is mostly used to switch off genes at later stages, when cells have already been tailored to specific functions, and those genes are less likely to be needed again.
Ethanol-induced alterations in SAMe levels can affect the methylation of histones or DNA, which in turn can modify gene expression, thereby contributing to liver injury (Lu and Mato 2012).
The findings are the first to illustrate crosstalk between mRNA and histone modifications, and may lead to new ways to target genes in the brain, Zhao said.
The histone H4 gene is supposed to be highly conserved among all organisms with the exception of variations found in the ciliate species.
Here, we show that FA readily forms adducts with histones in cells and dramatically decreases lysine acetylation of the cytosolic histones H3 and H4.
announced today that Eisai has entered into an exclusive license agreement with HUYA Bioscience International, LLC (San Diego, CA, USA) to develop and market the oral histone deacetylase (HDAC) inhibitor HBI-8000 in Japan, South Korea, Thailand, Malaysia, Indonesia, Philippines, Vietnam and Singapore.
15) Cruciferous vegetables such as kale, cabbage, brussels sprouts, and broccoli sprouts contain chemical components, such as sulforaphane (SFN) and indole-3-carbinol (I3C), which have been revealed to be regulators of microRNAs (miRNAs) and inhibitors of histone deacetylases (HDACs) and DNA methyltransferases (DNMTs).
In the mouse, histone acetylation of core histones (H3K9, H3K14, and H4K16) was rapidly deacetylated following SCNT, and reacetylation occurred after activation treatment.
Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells.
G9a histone methyltransferase catalyzes H3K9 methylation in mammals because disruption of the Gga gene resulted in a drastic decrease in H3K9 methylation [24-27].

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