histones

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histones

Strongly alkaline proteins associated with DNA. Histones may be released into the blood and appear in the urine when tissue breaks down in wasting illnesses.

References in periodicals archive ?

The researchers harvested satellite cells from both healthy and injured muscle tissue of young mice and from healthy tissue of old mice; extracted these cells' DNA with the histone coatings intact; and used tagged antibodies targeting the different kinds of marks to find which spots on those histones were flagged with either "stop" or "go" signals.

Scientists distinguish signatures of old versus young stem cells

So it makes sense that histone methylation is largely used to silence master genes that may be needed at multiple points during development, while DNA methylation is mostly used to switch off genes at later stages, when cells have already been tailored to specific functions, and those genes are less likely to be needed again.

How Genes Turn On and Off

Ethanol-induced alterations in SAMe levels can affect the methylation of histones or DNA, which in turn can modify gene expression, thereby contributing to liver injury (Lu and Mato 2012).

Epigenetic effects of ethanol on the liver and gastrointestinal system

The findings are the first to illustrate crosstalk between mRNA and histone modifications, and may lead to new ways to target genes in the brain, Zhao said.

Discovery Of Novel Gene Regulatory System May Advance Neural Stem Cell Treatments

The histone H4 gene is supposed to be highly conserved among all organisms with the exception of variations found in the ciliate species.

Phylogenetic Relationship of Locally Isolated Paramecium Species Inferred from Histone H4 Genes

Here, we show that FA readily forms adducts with histones in cells and dramatically decreases lysine acetylation of the cytosolic histones H3 and H4.

Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells

announced today that Eisai has entered into an exclusive license agreement with HUYA Bioscience International, LLC (San Diego, CA, USA) to develop and market the oral histone deacetylase (HDAC) inhibitor HBI-8000 in Japan, South Korea, Thailand, Malaysia, Indonesia, Philippines, Vietnam and Singapore.

Eisai Acquires Exclusive License from Huya Bioscience International to Develop and Market HDAC Inhibitor HBI-8000 in Japan and Other Asian Countries

Acetylated histones H3 and H4 were then determined by Western blotting.

Cross Talk Mechanism among EMT, ROS, and Histone Acetylation in Phorbol Ester-Treated Human Breast Cancer MCF-7 Cells

15) Cruciferous vegetables such as kale, cabbage, brussels sprouts, and broccoli sprouts contain chemical components, such as sulforaphane (SFN) and indole-3-carbinol (I3C), which have been revealed to be regulators of microRNAs (miRNAs) and inhibitors of histone deacetylases (HDACs) and DNA methyltransferases (DNMTs).

Epigenetics: nature meets nurture in psychiatry

In the mouse, histone acetylation of core histones (H3K9, H3K14, and H4K16) was rapidly deacetylated following SCNT, and reacetylation occurred after activation treatment.

Effects of trichostatin A on in vitro development of porcine embryos derived from somatic cell nuclear transfer

Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells.

High Expression of H3K9me3 Is a Strong Predictor of Poor Survival in Patients With Salivary Adenoid Cystic Carcinoma

G9a histone methyltransferase catalyzes H3K9 methylation in mammals because disruption of the Gga gene resulted in a drastic decrease in H3K9 methylation [24-27].

BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells