histone


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Related to histone: nonhistone

histone

 [his´tōn]
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as nucleic acids or the globin of hemoglobin.

his·tone (H),

(his'tōn),
One of a number of simple proteins (often found in the cell nucleus); contains a high proportion of basic amino acids; soluble in water, dilute acids, and alkalies; and not coagulable by heat; for example, the proteins associated with nucleic acids in the nuclei of plant and animal tissues. They constitute about half the mass of the chromosomes of eukaryotic cells.

histone

(hĭs′tōn′)
n.
Any of several basic proteins found in association with the DNA in the chromatin of eukaryotes.

his·tone

(his'tōn)
One of a number of simple proteins (often found in the cell nucleus) containing a high proportion of basic amino acids, are soluble in water, dilute acids, and alkalies, and are not coagulable by heat.

histone

a type of simple protein that is usually basic and tends to form complexes with nucleic acids (e.g. DNA) forming NUCLEOSOMES. CHROMOSOMES of EUKARYOTES contain large quantities of histones which may regulate DNA functioning in some way. The five major histones are represented as: H1, H2A, H2B, H3 and H4.
References in periodicals archive ?
"Unexpectedly, we found that yeast with fewer copies of histone genes lived longer than the controls," said first author Ruofan Yu, research assistant in molecular and human genetics in the Dang lab.
Yeast with a moderately low dose of histone genes showed a moderate reduction of histone gene expression and significant chromatin stress.
(1.) Marks PA, Richon VM, Rifkind RA, Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells.
The study confirms TSA-induced histone acetylation in PANC-1 cells and differentiation by increased expression of pancreatic differentiation markers.
Collectively, these PTMs have an influence on the structure and the level of condensation of the chromatin and are part of a "histone code" at the basis of gene regulation (30).
The study addressed the interaction between mRNA and histone modification in a genome-wide scale.
The fundamental unit of chromatin is the nucleosome, composed of DNA wrapped around an octamer of four core histone proteins (H2A, H2B, H3, and H4), each of which possesses a large number and type of modifiable residues [3,37].
The novel Camello HAT family has been identified in zebrafish and includes functional HAT showing specificity towards histone H4 and perinuclear localization [13].
Clozapine attenuated the decrease in histone H3 acetylation at lysine 9 residues in the prefrontal cortex and ameliorated memory impairments and social deficits in mice treated with phencyclidine [34].
Many studies have found that histone acetylation participates in experimental renal fibrosis (Figure 2).
reported that the level of histone H3 acetylation (H3ac) in the IL-6 promoter was significantly higher in RA synovial cells (SF) than in osteoarthritis (OA) SF [13].