histologically benign

histologically benign

A term of art referring to a lesion that does not meet any criteria of malignancy—e.g., marked cellular atypia, increased mitoses, disruption of basement membranes, metastasis. Histologically benign lesions may nonetheless be clinically malignant (e.g., craniopharyngiomas), as they compromise closed spaces or compress nerves and/or blood vessels that are difficult to manage.

histologically benign

adjective Referring to a lesion that does not meet any criteria of malignancy–eg, marked cellular atypia, ↑ mitosis, disruption of basement membranes, metastasize
References in periodicals archive ?
Kadonaga and Frieden in 1992 introduced the current criteria and defined NCM as a large nevus (>20 cm in adults and 9 cm on the head or 6 cm on the body in infants) or multiple nevi ([greater than or equal to] 3 lesions) without the evidence of cutaneous melanoma, except in cases where meningeal lesions are histologically benign or that of primary meningeal melanoma except in cases where the cutaneous lesion are benign.
Mucocoeles are histologically benign, epithelium-lined, mucus-containing sacs that affect the paranasal sinuses.
It is histologically benign but has a high rate of local recurrence (1) and can originate from musculoaponeurotic structures in any part of the body.
UL is a rare, histologically benign but biologically and clinically aggressive, clinical disease.[1],[2] It adheres to but does not invade the vessel wall.
(3) For the majority of cases in the AUS/FLUS and FN/SFN categories, lobectomy reveals a histologically benign nodule, and surgery may be regarded as overtreatment.
These studies have suggested a histologically benign disease in 17-45% of cases in different sets of data [8-10].
Despite being histologically benign, leiomyoma has clinically malignant potential.
Any histologically benign meningioma has the potential to metastasize [1].
Although IVL tumors are histologically benign, IVL is potentially life-threatening, as the tumor can extend into the inferior vena cava (IVC), right cardiac chambers, and pulmonary arteries.
It is a histologically benign tumor which may give local and distant metastasis.
(2) The majority of the latter are histologically benign. (3) Malignancies include gastrointestinal stromal tumors (GISTs), leiomyosarcomas, liposarcomas, fibrosarcomas, pleomorphic undifferentiated sarcomas, and hemangiopericytomas.
However, as most cytologically indeterminate nodules are histologically benign, and because two clinical validation studies demonstrated a high NPV for Afirma, performance can be estimated amongst the 1468 GEC tested cytologically indeterminate patients in the published literature by pooling them together and considering GEC benign patients with malignancy found at surgery (ten patients) as malignant (false negatives), and GEC benign patients that underwent surgery and were histologically benign as benign (true negatives), or were GEC benign and not operated (704 patients).