At initial diagnosis, age, axial localisation, metastatic status, and tumour size have been identified as prognostic factors in addition to histological response and surgical margins [21, 22].
Assessment of histological response in 5 cases yielded percentages of viable cells of 0,5,20,20, and 90% .
Because most relapses involved the lungs, the histological response to chemotherapy is difficult to assess and classify.
Our observation of relatively good radiological and histological response rates in this series and the relative safety of this strategy lead us to consider high dose thiotepa as an active drug in treatment of osteosarcoma.
Our study found no association between the level of TS expression and histological response to neoadjuvant chemotherapy.
(%) of patients Gender Male 33 (73%) Female 12 (27%) Tumour differentiation Well/moderate 29 (64%) Poor 16 (36%) Tumour site Gastric 17 (38%) GOJ 28 (62%) T stage 0/1 22 (49%) 2/3/4 23 (51%) N stage Node negative 14 (31%) Node positive 31 (69%) Vascular invasion No 38 (84%) Yes 8 (16%) Lymphatic invasion No 37 (82%) Yes 8 (18%) CRM Negative 35 (78%) Positive 10 (22%) Tumour recurrence Yes 29 (64%) No 16 (36%) Histological response Yes 4 (9%) No 41 (91%) CRM: circumferential resection margin.
Histological response to Peg IFN alpha-2a (40 KD) plus ribavirin in HIV-hepatitis C virus co-infection.
Relationship between biochemical, virological and histological response during interferon treatment of chronic hepatitis C.
Association of virological and histological responses in HCV/HIV co-infected patients was also observed by Lissen et al.