histiocytic lesion

An aggregate of histiocytes, which may be benign, indeterminant, or malignant in proliferative potential; to reduce confusion, it has been suggested that histiocytoses be subdivided into different categories

Histiocytic lesions-Behavior classification

Benign

• Familial histiocytosis with eosinophilia A chronic disease of infants with recurring bacterial infections, diarrhea, eczema, alopecia, associated with immunodeficiency

• Sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman disease A disease most common in adolescent blacks with massive cervical lymphadenopathy as well as enlargement of extranodal (orbit, skin, bone, salivary gland, testis) lymphoid tissues

• Virus-associated hemophagocytic syndrome A condition induced by viral infections, often accompanied by abnormal liver function tests, coagulation assays and pancytopenia Pathology Histiocyte hyperplasia, hemophagocytosis and replacement of native bone marrow elements

Intermediate

• Histiocytosis X, aka Langerhans' cell histiocytosis, see there.

• Reactive hemophagocytic syndrome, see there.

Malignant

• Histiocytic medullary reticulosis see there.

• Histiocytic proliferations, eg—acute monocytic leukemia (FAB M3), histiocytic lymphoma see there, malignant histiocytosis–see there.

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References in periodicals archive ?

CD68 may be used to rule out a histiocytic lesion, as abundant xanthomatous change within the schwannoma may introduce that possibility into the differential diagnosis.

Intraparotid Schwannoma

1) It is a rare, benign, non-Langerhans histiocytic lesion that typically arises in the head and neck, trunk, upper extremities, and lower extremities.

The differential diagnosis of JXG should include other histiocytic lesions, Rosai-Dorfman disease, and infectious causes.

Juvenile xanthogranuloma of the nasal vestibule

Juvenile xanthogranuloma (JXG) is a benign, non-Langerhans cell histiocytic lesion that generally affects infants and children.

Juvenile xanthogranuloma of the tympanic membrane: a case report

Thus, we consider that any histiocytic lesion with admixed prominent eosinophilic infiltrate requires immunohistochemical studies to rule out LCH.

Cutaneous Rosai-Dorfman disease with increased number of eosinophils: coincidence or histologic variant?

7) Soft tissue RDD presentation is with non-specific features, leading to misdiagnosis as benign inflammatory and fibro histiocytic lesions as well as lymphoma and malignant fibrous histiocytoma.

Soft tissue Rosai: Dorfman disease of the sacral region, a very rare disease: case report and review of literature

Histiocytic lesions and proliferations in the lung.

Crystal-storing histiocytosis complicating primary pulmonary marginal zone lymphoma of mucosa-associated lymphoid tissue