Scattered lymphocytes and Touton-type giant cells accompany the histiocytic
infiltrate in many cases.
Similar to the difficulties of diagnosing histiocytic
disease and monitoring treatment, collecting a sufficient biopsy in patient with metastatic lung cancer can be challenging, if not impossible, in some cases.
Ten years later, Dr MaurzioArico and his colleagues at the Histiocytic
Society supported results from the International HLH Registry, which showed that greater than 60% of the children with HLH who had a matched sibling transplant were alive after 5 years as compared to only 10% of children with HLH who had received chemotherapy alone (17).
RosaiDorfman disease (RDD) is rare and characterized by histiocytic
proliferation and massive cervical lymphadenopathy.
The most helpful clues in the diagnosis of LCS are the expression of several histiocytic
markers, such as CD68, and the weak expression of lysozyme.
Erdheim-Chester disease is a systemic histiocytic
disorder diagnosed on the basis of a characteristic pattern of symmetric intramedullary sclerosis of long bones.
Initially, MFH was defined as a neoplasm showing both fibroblastic and histiocytic
differentiation; but according to latest WHO nomenclature, in which significant changes in nomenclature of lipomatous and fibrous malignancies were made; there is no evidence of true histiocytic
differentiation and this morphological pattern is shared by a variety of poorly differentiated malignant neoplasms .
Treatment of histiocytic
necrotizing lymphadenitis (Kikuchi's disease) with prolonged fever by a single course of methylprednisolone pulse therapy without maintenance therapy: experience with 13 cases.
They include information on definitions, morphologic features, special stains, immunohistochemistry and flow cytometry techniques, differential diagnosis, diagnostic features, and special issues for normal findings; myeloproliferative neoplasms; neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1; myelodysplastic syndrome/myeloproliferative neoplasms; acute myeloid leukemia and related precursor neoplasms; precursor lymphoid neoplasms; mature B-cell neoplasms; mature T-cell and natural killer cell neoplasms; Hodgkin's lymphoma; histiocytic
and dendritic cell neoplasms; and immunodeficiency-associated lymphoproliferative disorders.
3) Most ALCLs in the literature are of B-cell type, (3) although cases of T-cell origin (4,5) and one case with histiocytic
features (6) have been described.
Commentary on the WHO 2008 classification of neoplasms arising from histiocytic
and other accessory cells.
Evidence suggests that its origins may be fibroblastic, neuroectodermal, histiocytic
, or a combination of the three due to mutations in multipotent cutaneous mesenchymal stem cells.