aTyr is focused on the therapeutic translation of the Resokine pathway, comprised of extracellular proteins derived from the histidyl
tRNA synthetase gene family.
Cadmium has affinity for hydroxyl, carboxyl, phosphatidyl, cysteinyl and histidyl
side chain groups of proteins, purines and porphyrins, and may interfere in different metabolic processes including oxidative phosphorylation pathways .
The most common is Jo-1 (histidyl
) (15%-30% prevalence), followed by PL-7 (threonyl) and PL-12 (alanyl), with a prevalence of 5% to 10%, followed by EJ (glycyl), OJ (isoleucyl), KS (asparaginyl), Zo (phenylalanyl), and YRS (tyrosyl) (all with prevalences of 1%-5%).
Shilpa, "Interaction of DNA with small molecules: Role of copper histidyl
peptide complexes in DNA binding and hydrolytic cleavage," Indian Journal of Chemistry --Section A Inorganic, Physical, Theoretical and Analytical Chemistry, vol.
Kasprzak, "Generation of free radicals from model lipid hydroperoxides and H2O2 by Co(II) in the presence of cysteinyl and histidyl
chelators," Chemical Research in Toxicology, vol.
Kostic, "Effects of linkage isomerism and of acid-base equilibria on reactivity and catalytic turnover in hydrolytic cleavage of histidyl
peptides coordinated to palladium(II).
Mutations in mitochondrial histidyl
tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome.
Detection, characterisation, and quantification of carnosine and other histidyl
derivatives in cardiac and skeletal muscle.
These intermediates cross-link with histidyl
residues of cuticular proteins and chitin, hardening the exoskeletons (Xu et al.
(32) Both carnosine and anserine are antioxidative histidyl
dipeptides and the most abundant antioxidants in meat.
The sequencing of albumin-adduct tryptic peptides and the analysis of pronase/amino peptidase digests demonstrated that lysyl, cysteinyl, and histidyl
residues are involved in the formation of these adducts.
The ND3/ND4 region begins in the glycyl tRNA gene and spans the NADH-dehydrogenase subunit-3, arginyl tRNA, NADH-dehydrogenase subunit-4L, and NADH-dehydrogenase subunit-4 genes, ending in the histidyl