The alcohol analogue of histidine (-COOH becomes -CH2OH).
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Cells were cultured in RPMI-1640 medium supplemented with 10% (v/v) HIHS, 2 mM L-glutamine, 100 U/mL penicillin, 100 [micro]g/mL streptomycin, 2 mM histidinol, and 200 [micro]g/mL hygromycin B; this medium was called R10.
Among specific topics are anti-glaucoma carbonic anhydrase inhibitors as opthalmologic drugs, crystallographic studies of carbonic anydrases from fungal pathogens for structure-assisted drug development, sulfonylated matrix metalloproteinase inhibitors, Clostridium histolyticum collagenase inhibitors in the drug design, angiotensin converting enzyme inhibitors, and inhibitors of histidinol dehydrogenases as antibacterial agents.
Referring to Figure 1, all compounds are derivatives of carboxylic or phosphoric acid or both, with the exception of histidinol and histidinal.