(8) in H4 receptor-knockout mice showed that these receptors modulate various neurophysiological functions, such as anxiety, locomotor activity, and nociception, indicating the importance of the integrity and functionality of the H4 receptors in the histaminergic
regulation of neuronal functions.
In Europe, the most frequently prescribed drug in the treatment of MD is betahistine, a weak H1 agonist and strong H3 antagonist histaminergic
Klyuch et al., "Excitation of histaminergic
tuberomamillary neurons by thyrotropin-releasing hormone," The Journal of Neuroscience, vol.
Neuromodulation and the waking state are related to histaminergic
Drug-induced histamine release from mast cells/ basophils occurs as a result either of an IgE-dependent allergic reaction or of direct IgE-independent degranulation of these cells resulting in histaminergic
Agonists (acetylcholine, histamine) and their appropriate antagonists (atropine, H1 blocker-pheniramine maleate) were used to evaluate the cholinergic and histaminergic
The product is a selective histamine H3-receptor antagonist/inverse agonist that improves the activity of histaminergic
granatum produced spasmogenic activity possibly through involvement of cholinergic and histaminergic
Damage to histaminergic
tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury.
This result may be due to serotonin modulation as mentioned above or some other mechanisms including histaminergic
Pimavanserin, a selective 5-HT2A inverse agonist without dopaminergic, adrenergic, histaminergic
, or muscarinic effect , has been approved by the FDA  in September 2014 and has shown to be effective and safe in the treatment of PD psychosis, reducing hallucinations and delusions without affecting motor function [143, 144], which is a commonly observed drawback of most antipsychotic drugs due to dopamine antagonism.
It is therefore reasonable to propose that the extract may act directly on the histaminergic
receptor or in its signaling pathway, since the effect on the muscarinic (M3) and [Ca.sup.2+] influx through VACCs was not altered by the presence of the extract.