Loynds et al., "Anticoagulant activity of Hirulog
, a direct thrombin inhibitor, in humans," Thrombosis and Haemostasis, vol.
Unexplained International Differences in Clinical Outcomes after Acute Myocardial Infarction and Fibrinolytic Therapy: Lessons from the Hirulog
and Early Reperfusion or Occlusion (HERO)-2 Trial.
Prognostic differences between different types of bundle branch block during the early phase of acute myocardial infarction: insights from the Hirulog
and Early Reperfusion or Occlusion (HERO)-2 trial.
They assessed the consent process at a medical center where more than 300 patients were invited to participate in the multicenter HERO-2 trial (Hirulog
and Early Reperfusion or Occlusion) during ER admission for acute MI.
Successful treat-merit of heparin-associated thrombocytopenia and thrombosis using Hirulog
. Canadian Journal of Cardiology, 11, 511-514.
Heparine bagli trombositopeni oykusu olan hastalarda antikoagulasyon icin hirudin (Refludan), bivalirudin (Hirulog
), and argatroban kullanilmaktadir.
A similar decrease of soluble P-selectin levels was also noted when HIT patients were treated with other direct thrombin agents (eg, hirudin and hirulog
) as alternative anticoagulation therapies. Since thrombin plays an important role in the activation of platelets, resulting in microparticle formation, the selectin-level down-regulation may be related to the inhibition of thrombin generation.
Recombinant hirudin, glycoprotein IIb/IIIa-targeting antibodies, synthetic peptides such as hirulog
, and efegatran[R] are being tested for their efficacy.
Semptomlari n baslangicindan trombolitik tedavi baslayana kadar gecen sure GUSTO (Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries), ASSENT (Assessment of the Safety and Efficacy of a New Thrombolytic) ve HERO (Hirulog
and Early Reperfusion/Occlusion) gibi cok merkezli, buyuk calismalarda bile 3 saati asmaktadir (34).
Fenton, "Design and Characterization of Hirulogs
: A Novel Class of Bivalent Peptide Inhibitors of Thrombin," Biochemistry, vol.