hirudin


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Related to hirudin: Lepirudin, Bivalirudin, Desirudin

hirudin

 [hĭ-roo´din]
the active principle of the buccal secretion of leeches; it prevents clotting of the blood. A product made with recombinant technology is used as an anticoagulant.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

hir·u·din

(hir'ū-din),
An antithrombin substance extracted from the salivary glands of the leech that has the property of preventing coagulation of the blood.
[L. hirudo, leech]
Farlex Partner Medical Dictionary © Farlex 2012

hirudin

(hîr-o͞od′n, hîr′ə-dən, -yə-)
n.
A substance secreted by the buccal glands of leeches, capable of preventing coagulation by inactivating thrombin and used in medicine as an anticoagulant.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

hirudin

Hematology The most potent known inhibitor of thrombin, produced by the medicinal leech, Hirudo medicinalis
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

hir·u·din

(hir-ū'din)
An antithrombin substance extracted from the salivary glands of the leech that has the property of preventing coagulation of the blood.
[L. hirudo, leech]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

hirudin

A substance secreted by the salivary glands of leeches to prevent blood coagulation so that they can continue to feed on blood. The leeches are, of course, unaware that their hirudin acts by binding directly to thrombin molecules thus preventing them from converting soluble fibrinogen to fibrin. Hirudin has been found capable of preventing restenosis after coronary angioplasty.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Blood was obtained from a healthy volunteer in a hirudin blood tube (Roche Diagnostics, Switzerland) and diluted in RPMI-HSA.
Markwardt, "Biochemistry and pharmacology of hirudin," International Journal of Hematology, vol.
The levels of OPN-C and OPN-N correlate with the disease's severity, and the thrombin inhibitor hirudin ameliorates collagen-induced arthritis [149].
Neuhaus, "Thrombin generation in patients with acute myocardial infarction treated with front-loaded rt-PA and recombinant hirudin (HBW 023)," Journal of Thrombosis and Thrombolysis, vol.
For platelet aggregation testing, the whole blood was collected into the Sarstedt S-Monovette Hirudin tube (number 04.1944.001).
Gaffney, "An international collaborative study to investigate standardisation of hirudin potency," Thrombosis and Haemostasis, vol.
Wedi torri'r croen a chwistrellu gwrthgeulydd (hirudin) ac anaesthetig i mewn, maen nhw'n dechrau sugno gwaed.
A previous report indicated efficient secretory expression of recombinant hirudin III in E.
(64.) Nowak G, Bucha E: A new method for the therapeutical monitoring of hirudin. Thromb Haemost 1993;69:1306.
In patients with HIT, heparin should be avoided to prevent recurrent HIT and PCI should be performed using alternative anticoagulants including direct thrombin inhibitors without cross-reactivity with HIT antibodies, such as argatroban, bivalirudin, and hirudin. No platelet transfusions in our patient may be appropriate after concerns about increased risk of thrombotic events in case of gradually increased platelet count.
Along with the natural anesthetic that helps dull the pain of their initial chomp, leeches release several compounds when feeding, including hirudin, an anticoagulant that maintains blood flow during feeding; and calM, which inhibits clotting for a period afterward.