hirudin


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Related to hirudin: Lepirudin, Bivalirudin, Desirudin

hirudin

 [hĭ-roo´din]
the active principle of the buccal secretion of leeches; it prevents clotting of the blood. A product made with recombinant technology is used as an anticoagulant.

hir·u·din

(hir'ū-din),
An antithrombin substance extracted from the salivary glands of the leech that has the property of preventing coagulation of the blood.
[L. hirudo, leech]

hirudin

/hi·ru·din/ (hĭ-rldbomacd´in) the active principle of the buccal secretion of leeches; it prevents coagulation by acting as an antithrombin.

hirudin

(hîr-o͞od′n, hîr′ə-dən, -yə-)
n.
A substance secreted by the buccal glands of leeches, capable of preventing coagulation by inactivating thrombin and used in medicine as an anticoagulant.

hirudin

Hematology The most potent known inhibitor of thrombin, produced by the medicinal leech, Hirudo medicinalis

hir·u·din

(hir-ū'din)
An antithrombin substance extracted from the salivary glands of the leech that has the property of preventing coagulation of the blood.
[L. hirudo, leech]

hirudin

A substance secreted by the salivary glands of leeches to prevent blood coagulation so that they can continue to feed on blood. The leeches are, of course, unaware that their hirudin acts by binding directly to thrombin molecules thus preventing them from converting soluble fibrinogen to fibrin. Hirudin has been found capable of preventing restenosis after coronary angioplasty.

hirudin

the active principle of the buccal secretion of leeches; it prevents clotting of the blood.
References in periodicals archive ?
Taken together, although native and mutant L-asparaginase II signal peptide were efficient for recombinant hirudin III and cyclodextrin glucanotransferase secretion in E.
Haas, like Abel, also used hirudin as the anticoagulant in his first dialysis (Counts, 2006).
Recombinant hirudin is available to physicians as an intravenous anticoagulant preparation for injection, particularly useful for patients who are allergic to or cannot tolerate heparin.
I do try and learn a few of the definitions to give the words some life, but hirudin is quite a low probability word.
I do try and learn a few to give the words some life, but hirudin is quite a low probability word.
Bleeding occurs as a result of the injection of the antithrombin hirudin and a histamine-like substance that causes vasodilatation and prevents capillary closure.
Hirudin, the first parenteral DTI to be used, was isolated in the late 1800s from the medicinal leech.
While leeches suck blood, their saliva contains healing compounds, including anticoagulant hirudin, which prevents the clotting and congestion of blood.
Derived from hirudin found in the saliva of medicinal leeches, (5) these drugs bind directly to thrombin and prevent the conversion of fibrinogen to fibrin (fig 3).
Influence of different anticoagulants on platelet aggregation in whole blood : A comparison between citrate, low molecular mass heparin and hirudin.
It is a recombinant form of hirudin, a protein isolated from salivary glands of leech, and metabolized in kidneys.
Successful use of recombinant hirudin and its monitoring by ecarin clotting time in patients with heparin-induced thrombocytopenia undergoing off pump coronary artery revascularization.