Hypoxic preconditioning failure in aging
hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation.
Hippocampal slices from PD5 Sprague-Dawley rats were cultured for 3 days as described (Lein et al.
Hippocampal atrophy has been identified as a common feature in Alzheimer's disease, and shrinkage in the
hippocampal region has been shown to correlate with severity of the patient's decline.
Our findings provide a better understanding of what causes the
hippocampal changes and how they are related to communication across a network of areas involved in learning and representing cognitive maps of the world around us.
Although TEN has been reported to improve the basic synaptic transmission in
hippocampal brain slices of mice (Huang et al.
Researchers found that 5-hydroxymethylfurfural could protect against H2O2-induced rat
hippocampal neuron apoptosis by regulation of expression levels of the apoptosis-related genes p53, bcl-2, bax and caspases.
The quantitative measurement of lipid peroxidation in the
hippocampal homogenate was performed according to the method previously described by Ohkawa et al.
Sickle cell patients also had significant loss in both right and left
hippocampal volume, compared with controls.
It is significant that the change in the
hippocampal volume corresponds to both PTSD symptom severity and increased cortisol levels.
In separate experiments in cultured
hippocampal neurons, PS enhanced NMDA-evoked whole-cell currents (EC50 = 16 microM).
2] adrenergic receptor (AR) activation by epinephrine (EPI) inhibits epileptiform activity in the mouse
hippocampal CA3 region.
MONTREAL -- Teenagers who report heavy alcohol use have reduced
hippocampal volume, compared with their nondrinking peers, but those who combine marijuana with heavy drinking do not show these abnormalities, Susan Tapert, Ph.
