hinge region

hinge re·gion

1. that part of a tRNA structure that is deformed, bending a "cloverleaf" (two-dimensional) model to form an "L" model (crystal form, as seen by electron microscopy);
2. in an immunoglobulin, a short sequence of amino acids that lies between two longer sequences and allows the latter to bend about the former.

hinge re·gion

(hinj rē'jŭn)
1. That part of a tRNA structure that is deformed, bending a "cloverleaf" (two-dimensional) model to form an "L" model (crystal form, as seen by electron microscopy).
2. In an immunoglobulin, a short sequence of amino acids that lies between two longer sequences and allows the latter to bend about the former.

hinge region

The part of the immunoglobulin (antibody) molecule between the Fab and Fc regions that allows flexibility.
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References in periodicals archive ?
It is a transcription factor and its three domains are firstly the DNA binding domain, secondly the ligand binding domain and thirdly the hinge region connecting the two.
Unless special measures are taken to move the plastic hinge region away from the face of the column, the onset of yielding in the beam will penetrate the column area.
In a cantilever member, the curvature distribution of plastic hinge region is very irregular (Figure 8(b)).
This result indicated that the hinge region (H) and the ligand-binding domain (LBD), shared by mutants 2 and 3 of ER[alpha], were preferentially ubiquitinated by Hbo1.
The first one is the hydrophobic switch L203-Y229 that contains hinge region D227-I232 and links B/C-helix (Y229) directly to L203 of phosphate binding cassette (PBC) [2, 3].
The common feature, bZIP domain with length ranging from 60 to 80 amino acids (aa), includes two unique structures, a highly conserved DNA-binding basic and hinge region and a relatively diversified leucine zipper region [3].
A hinge region and the cysteine-rich domains on the WW domain (WW domain is an overlapping part of the central rod domain and the cysteine-rich domain, named after the presence of two conserved tryptophans (W)) [33-34], as well as the EF hand-shaped region, form together Batch 4.
In addition to the plastic hinge length [l.sub.p], [l.sub.pr] is also referred to the length of plastic hinge region. The length of plastic hinge region, [l.sub.pr], is the physical length over which plasticity actually spreads, which only refers to the length along the pier and does not take into account any penetration of inelastic strain into the footing.
Generally, in order to avoid catastrophic fragility failure of bridge structure system, it is desired to dissipate energy by postelastic deformation in potential plastic hinge region of bridge pier.
IgA1 O-glycosylation sites are located in the hinge region, with 3-6 O-glycans per heavy chain.
Deletion of hinge region of human myeloma IgG1 molecule (protein LEC) associated with nonexpression of G1m(3) and Km(1,2) allotypes.
This is particularly true for etanercept where antibodies are typically directed against the hinge region of the fusion protein.