This is particularly true for etanercept where antibodies are typically directed against the hinge region of the fusion protein.
Antibodies to fusion proteins, such as etanercept or abatacept, may be directed against the antigen binding site or against structural epitopes such as the hinge region of etanercept.
Deletion of hinge region
of human myeloma IgG1 molecule (protein LEC) associated with nonexpression of G1m(3) and Km(1,2) allotypes.
Acetate peel replicas of the shell margin (marginal increment analysis) and hinge region of the shell were used to validate an annual periodicity of growth lines and to determine shell age, respectively.
Marginal increment analysis was used to validate the periodicity of formation of the internal shell growth lines, and shell age was estimated from the hinge region of the shell.
htm), except the near-central region of ORF1, which showed less similarity among aHEV strains; this region encodes the hinge region
flanking the papain-like protease and the X domain.
Mutations are located in the T3-binding domain and its adjacent hinge region
In particular, each receptor cassette encodes a receptor polypeptide that comprises a DNA binding domain, a hinge region
, a ligand binding domain and an activation domain.
This paper presents an archaeological application of a new method to study the growth patterns of Mya arenaria, the soft-shell clam common along North Atlantic and North Pacific coasts, by cross-sectioning the chondrophore, a small appendage on the hinge region
of the left valve that preserves well in archaeological contexts.
Besides the lack of the hinge region
, some of Genmab's monovalent UniBody([R]) molecules differ only in a few amino acids compared to the native homodimer IgG4 molecules, and the challenge was to create affinity ligands targeting those regions.
Annually resolved growth lines in the hinge region
and margin of the shell were identified and counted; the age of the oldest clam shell was determined to be at least 106 y.
Notably, residue 131 in the envelope gene is located within a pH-dependent hinge region
at the interface between domains I and II of the envelope protein.