hinge region

hinge re·gion

1. that part of a tRNA structure that is deformed, bending a "cloverleaf" (two-dimensional) model to form an "L" model (crystal form, as seen by electron microscopy);
2. in an immunoglobulin, a short sequence of amino acids that lies between two longer sequences and allows the latter to bend about the former.

hinge re·gion

(hinj rē'jŭn)
1. That part of a tRNA structure that is deformed, bending a "cloverleaf" (two-dimensional) model to form an "L" model (crystal form, as seen by electron microscopy).
2. In an immunoglobulin, a short sequence of amino acids that lies between two longer sequences and allows the latter to bend about the former.

hinge region

The part of the immunoglobulin (antibody) molecule between the Fab and Fc regions that allows flexibility.

hinge region

a proline-rich portion of an immunoglobulin heavy chain between the Fc and Fab regions that confers mobility on the two Fab arms of the antibody molecule thereby allowing it to combine better with the two epitopes.
References in periodicals archive ?
This is particularly true for etanercept where antibodies are typically directed against the hinge region of the fusion protein.
Antibodies to fusion proteins, such as etanercept or abatacept, may be directed against the antigen binding site or against structural epitopes such as the hinge region of etanercept.
Deletion of hinge region of human myeloma IgG1 molecule (protein LEC) associated with nonexpression of G1m(3) and Km(1,2) allotypes.
Acetate peel replicas of the shell margin (marginal increment analysis) and hinge region of the shell were used to validate an annual periodicity of growth lines and to determine shell age, respectively.
Marginal increment analysis was used to validate the periodicity of formation of the internal shell growth lines, and shell age was estimated from the hinge region of the shell.
htm), except the near-central region of ORF1, which showed less similarity among aHEV strains; this region encodes the hinge region flanking the papain-like protease and the X domain.
In particular, each receptor cassette encodes a receptor polypeptide that comprises a DNA binding domain, a hinge region, a ligand binding domain and an activation domain.
This paper presents an archaeological application of a new method to study the growth patterns of Mya arenaria, the soft-shell clam common along North Atlantic and North Pacific coasts, by cross-sectioning the chondrophore, a small appendage on the hinge region of the left valve that preserves well in archaeological contexts.
Besides the lack of the hinge region, some of Genmab's monovalent UniBody([R]) molecules differ only in a few amino acids compared to the native homodimer IgG4 molecules, and the challenge was to create affinity ligands targeting those regions.
Annually resolved growth lines in the hinge region and margin of the shell were identified and counted; the age of the oldest clam shell was determined to be at least 106 y.
Notably, residue 131 in the envelope gene is located within a pH-dependent hinge region at the interface between domains I and II of the envelope protein.