This result indicated that the hinge region
(H) and the ligand-binding domain (LBD), shared by mutants 2 and 3 of ER[alpha], were preferentially ubiquitinated by Hbo1.
A hinge region
and the cysteine-rich domains on the WW domain (WW domain is an overlapping part of the central rod domain and the cysteine-rich domain, named after the presence of two conserved tryptophans (W)) [33-34], as well as the EF hand-shaped region, form together Batch 4.
This is particularly true for etanercept where antibodies are typically directed against the hinge region
of the fusion protein.
Deletion of hinge region
of human myeloma IgG1 molecule (protein LEC) associated with nonexpression of G1m(3) and Km(1,2) allotypes.
Acetate peel replicas of the shell margin (marginal increment analysis) and hinge region
of the shell were used to validate an annual periodicity of growth lines and to determine shell age, respectively.
htm), except the near-central region of ORF1, which showed less similarity among aHEV strains; this region encodes the hinge region
flanking the papain-like protease and the X domain.
modification: The design of CH1 (heavy chain constant domain1) gene segment, which encodes part of the antibody hinge region
containing cysteines, was modified to convert two cysteines out of three to alanines.
Mutations are located in the T3-binding domain and its adjacent hinge region
In particular, each receptor cassette encodes a receptor polypeptide that comprises a DNA binding domain, a hinge region
, a ligand binding domain and an activation domain.
Besides the lack of the hinge region
, some of Genmab's monovalent UniBody([R]) molecules differ only in a few amino acids compared to the native homodimer IgG4 molecules, and the challenge was to create affinity ligands targeting those regions.
Annually resolved growth lines in the hinge region
and margin of the shell were identified and counted; the age of the oldest clam shell was determined to be at least 106 y.
Notably, residue 131 in the envelope gene is located within a pH-dependent hinge region
at the interface between domains I and II of the envelope protein.