high-molecular-weight kininogen

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high-molecular-weight kininogen



A protein kininogen that is one of the early participants of the intrinsic pathway of coagulation and functions as a cofactor for activating kallikrein and the Hageman factor.
See: coagulation factor under factor
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
An isolated aPTT prolongation suggests a deficiency or inhibitor of one or more of the intrinsic pathway clotting factors including prekallikrein, high-molecular-weight kininogen, and factors XII, XI, IX, and VIII.
In affected patients, "activation of the kallikreinkinin cascade leads to uncontrolled generation of plasma kallikrein and consequent proteolysis of high-molecular-weight kininogen. This results in excessive bradykinin production, which causes vasodilation, vascular leakage, and subsequent angioedema and pain," said Aleena Banerji, MD, of Massachusetts General Hospital, Boston, and her associates (N Engl J Med.
Pharmacodynamic assessments showed that lanadelumab inhibited kallikrein in a linear, dose-dependent manner, and the two higher doses reduced levels of cleaved high-molecular-weight kininogen to those reported in healthy controls.

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