high-molecular-weight kininogen


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high-molecular-weight kininogen

,

HWMK

A protein kininogen that is one of the early participants of the intrinsic pathway of coagulation and functions as a cofactor for activating kallikrein and the Hageman factor.
See: coagulation factor under factor
Medical Dictionary, © 2009 Farlex and Partners
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An isolated aPTT prolongation suggests a deficiency or inhibitor of one or more of the intrinsic pathway clotting factors including prekallikrein, high-molecular-weight kininogen, and factors XII, XI, IX, and VIII.
A Case of a Patient Who Is Diagnosed with Mild Acquired Hemophilia A after Tooth Extraction Died of Acute Subdural Hematoma due to Head Injury
In affected patients, "activation of the kallikreinkinin cascade leads to uncontrolled generation of plasma kallikrein and consequent proteolysis of high-molecular-weight kininogen. This results in excessive bradykinin production, which causes vasodilation, vascular leakage, and subsequent angioedema and pain," said Aleena Banerji, MD, of Massachusetts General Hospital, Boston, and her associates (N Engl J Med.
Pharmacodynamic assessments showed that lanadelumab inhibited kallikrein in a linear, dose-dependent manner, and the two higher doses reduced levels of cleaved high-molecular-weight kininogen to those reported in healthy controls.
Lanadelumab reduced hereditary angioedema attacks by 88%-100%

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