high-grade squamous intraepithelial lesion


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Related to high-grade squamous intraepithelial lesion: HSIL

high-grade squamous intraepithelial lesion (HSIL, HGSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion.

high-grade squamous intraepithelial lesion

Gynecology
A lesion defined by cytologic findings–cells occur singly or in syncytia-like sheets, ↑ nuclear:cytoplasmic ratio, nuclear hyperchromasia that translate into moderate-to-severe dysplasia–CIN 2 to 3/carcinoma in situ of the uterine cervix–a diagnosis made on histology of biopsied tissue, a precancerous lesion. Cf Low-grade squamous intraepithelial lesion.

high-grade squa·mous in·tra·ep·i·the·li·al le·sion

(HSIL, HGSIL) (hī-grād skwā'mŭs in'tră-ep-i-thē'lē-ăl lē'zhŭn)
Term used in the Bethesda system for reporting cervical-vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion

high-grade squamous intraepithelial lesion

Abbreviation: HGSIL
A premalignant squamous lesion, found on the Papanicolaou test, which may be moderate dysplasia, severe dysplasia, or carcinoma in situ.

Patient care

Treatment requires removal or destruction of the affected cells, usually with loop electrosurgical excision procedure (LEEP) or ablation. Left untreated, HGSIL may progress to invasive cervical cancer.

See also: lesion
References in periodicals archive ?
Clinical importance of "low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H)" terminology for cervical smears: 5-year analysis of the positive predictive value of LSIL-H compared with ASC-H, LSIL, and HSIL in the detection of high-grade cervical lesions with a review of the literature.
High-grade squamous intraepithelial lesion was the second most-common, abnormal Pap test result in 917 of 3649 patients (25.
Perhaps a more fruitful way to detect more false-negative Pap findings in retrospective rescreening is to also include cervical biopsy specimens diagnostic of a high-grade squamous intraepithelial lesion or worse to trigger review.
At our institution, most high-grade squamous intraepithelial lesions (HSILs) corresponding to cervical intraepithelial neoplasia (CIN) II and III are treated by loop electrosurgical excision procedure (LEEP).
The recommended terminology for HPV-associated squamous lesions of the LAT is low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), which may be further classified by the applicable -IN subcategorization.
Follow-up findings in young females with high-grade squamous intraepithelial lesion Papanicolaou test results.
None of the patients followed only with cytology had high-grade squamous intraepithelial lesion results reported.
Slides with cytologic abnormalities were a mix of low-grade and high-grade squamous intraepithelial lesions, independently prevalidated by 3 expert cytologists.
This finding corroborates a previous study performed by us [33] that showed a progressive increase of VEGF immunoexpression in high-grade squamous intraepithelial lesions when compared to low-grade squamous intraepithelial lesions and to benign squamous epithelium.
The topics include colposcopy, negative for intraepithelial lesion and malignancy, low-grade and high-grade squamous intraepithelial lesions, atypical squamous cells of uncertain significance, adenocarcinoma, and cervical cancer screening and follow-up of limited and abnormal screen results.
In this observational study of 690 women referred to colposcopy for abnormal cervical screening results, the sensitivity of biopsy in the detection of high-grade squamous intraepithelial lesions (HSIL) increased from 60.