high-grade squamous intraepithelial lesion


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Related to high-grade squamous intraepithelial lesion: HSIL

high-grade squamous intraepithelial lesion (HSIL, HGSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion.

high-grade squamous intraepithelial lesion

Gynecology
A lesion defined by cytologic findings–cells occur singly or in syncytia-like sheets, ↑ nuclear:cytoplasmic ratio, nuclear hyperchromasia that translate into moderate-to-severe dysplasia–CIN 2 to 3/carcinoma in situ of the uterine cervix–a diagnosis made on histology of biopsied tissue, a precancerous lesion. Cf Low-grade squamous intraepithelial lesion.

high-grade squa·mous in·tra·ep·i·the·li·al le·sion

(HSIL, HGSIL) (hī-grād skwā'mŭs in'tră-ep-i-thē'lē-ăl lē'zhŭn)
Term used in the Bethesda system for reporting cervical-vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion

high-grade squamous intraepithelial lesion

Abbreviation: HGSIL
A premalignant squamous lesion, found on the Papanicolaou test, which may be moderate dysplasia, severe dysplasia, or carcinoma in situ.

Patient care

Treatment requires removal or destruction of the affected cells, usually with loop electrosurgical excision procedure (LEEP) or ablation. Left untreated, HGSIL may progress to invasive cervical cancer.

See also: lesion
References in periodicals archive ?
Clinical importance of "low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H)" terminology for cervical smears: 5-year analysis of the positive predictive value of LSIL-H compared with ASC-H, LSIL, and HSIL in the detection of high-grade cervical lesions with a review of the literature.
Abbreviations: AGC, atypical glandular cells; AIS, adenocarcinoma in situ; ASC-H, atypical squamous cells, a high-grade squamous intraepithelial lesion cannot be ruled out; ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; LSIL-H, low-grade squamous intraepithelial lesion, a high-grade squamous intraepithelial lesion cannot be ruled out; SCCA, squamous cell carcinoma.
PDPN and VEGF immunoexpressions were simultaneously compared in the same fragments of low- and high-grade squamous intraepithelial lesions, but we did not find any statistical significance.
In this observational study of 690 women referred to colposcopy for abnormal cervical screening results, the sensitivity of biopsy in the detection of high-grade squamous intraepithelial lesions (HSIL) increased from 60.6% (95% confidence interval [CI], 54.8-66.6) for a single biopsy to 95.6% (95% CI, 91.3-99.2) for three biopsies.
Any women with cervical high-grade squamous intraepithelial lesions (HSIL) and anyone with abnormal anal findings should be referred for high-resolution anoscopy and/or examination with biopsy of abnormal tissue.
Box 1: Description of anal cytology terminology Unsatisfactory due to inadequate cellularity Negative for intraepithelial lesion or malignancy Atypical squamous cells of undetermined significance (ASCUS) Low-grade squamous intraepithelial lesions (LSIL) High-grade squamous intraepithelial lesions (HSIL) There are few studies comparing anal cytology efficacy in detecting intraepithelial lesions with other methods such anoscopy and histology.
We evaluated 109 exocervix samples spanning the spectrum from normal cervical tissue to high-grade squamous intraepithelial lesions. Samples were obtained from women who visited the gynecological out-patient clinic of The Manuel Noriega-Trigo Hospital, National Health Clinic "La Victoria" and private practice.
"High-grade lesions are rare in teenagers, occurring in 3 cases per 1,000 15-to 19-year-olds, and they take years after sexual debut for high-grade squamous intraepithelial lesions to develop and 5 years for invasive cancers to emerge," he said at a conference on contraceptive technology sponsored by Contemporary Forums.
According to the 2001 guidelines, these women were treated according to recommendations for high-grade squamous intraepithelial lesions (HSIL).
Recruitment is ongoing for patients who are HIV-negative with histologically confirmed anal or perianal high-grade squamous intraepithelial lesions associated with HPV-16 and/or HPV-18.
Among those women vaccinated between 15 and 17 years of age and followed for a median of 3.1 years, adjusted vaccine effectiveness (VE) was a nonstatistically significant 35% against high-grade squamous intraepithelial lesions (HSILs) and 21% against low-grade squamous intraepithelial lesions (LSILs).
Have we not seen evidence that a young woman's immune system can fail to suppress the human papillomavirus (HPV) enough to prevent high-grade squamous intraepithelial lesions (HSIL)?