high-grade squamous intraepithelial lesion


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Related to high-grade squamous intraepithelial lesion: HSIL

high-grade squamous intraepithelial lesion (HSIL, HGSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion.

high-grade squamous intraepithelial lesion

Gynecology
A lesion defined by cytologic findings–cells occur singly or in syncytia-like sheets, ↑ nuclear:cytoplasmic ratio, nuclear hyperchromasia that translate into moderate-to-severe dysplasia–CIN 2 to 3/carcinoma in situ of the uterine cervix–a diagnosis made on histology of biopsied tissue, a precancerous lesion. Cf Low-grade squamous intraepithelial lesion.

high-grade squa·mous in·tra·ep·i·the·li·al le·sion

(HSIL, HGSIL) (hī-grād skwā'mŭs in'tră-ep-i-thē'lē-ăl lē'zhŭn)
Term used in the Bethesda system for reporting cervical-vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities, including moderate and severe dysplasia, carcinoma in situ, and cervical intraepithelial neoplasia grades 2 and 3.
See also: Bethesda system, ASCUS, atypical glandular cells of undetermined significance, low-grade squamous intraepithelial lesion

high-grade squamous intraepithelial lesion

Abbreviation: HGSIL
A premalignant squamous lesion, found on the Papanicolaou test, which may be moderate dysplasia, severe dysplasia, or carcinoma in situ.

Patient care

Treatment requires removal or destruction of the affected cells, usually with loop electrosurgical excision procedure (LEEP) or ablation. Left untreated, HGSIL may progress to invasive cervical cancer.

See also: lesion
References in periodicals archive ?
Follow-up findings in adolescents with high-grade squamous intraepithelial lesion Papanicolaou test results.
Abbreviations: AGC, atypical glandular cells; AIS, adenocarcinoma in situ; ASC-H, atypical squamous cells, a high-grade squamous intraepithelial lesion cannot be ruled out; ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; LSIL-H, low-grade squamous intraepithelial lesion, a high-grade squamous intraepithelial lesion cannot be ruled out; SCCA, squamous cell carcinoma.
Any women with cervical high-grade squamous intraepithelial lesions (HSIL) and anyone with abnormal anal findings should be referred for high-resolution anoscopy and/or examination with biopsy of abnormal tissue.
0) ASCUS = atypical squamous cells of undetermined significance; ASC-H = atypical squamous cells --cannot exclude HSIL; AGUS = atypical glandular cells of undetermined significance; LSILs = low-grade squamous intraepithelial lesions; HSILs = high-grade squamous intraepithelial lesions.
Although consensus guidelines for the general population call for reflex human papillomavirus (HPV) testing for women with ASC-US and colposcopic examination of the of the cervix for those with evidence of HPV infection, LSIL, and high-grade squamous intraepithelial lesions (HSIL), these guidelines do not apply to adolescents and young women, he said.
Also, early data suggest that the cocktail results in near-perfect accuracy for detecting high-grade squamous intraepithelial lesions (a condition characterized by the presence of pre-cancerous cells) and cancer.
Guidelines from the American Cancer Society, the American College of Obstetricians and Gynecologists, and the American Society for Colposcopy and Cervical Pathology state that HPV DNA testing is not recommended for certain situations, including low-risk HPV types, routine cervical cancer screening in women younger than 30 years, routine screening more often than 3 years in women older than 30 years, routine sexually transmitted disease screenings, sexual assault work-ups, and initial triage of women with Pap test results of high-grade squamous intraepithelial lesions or of ASC-H, the researchers said.
According to the 2001 guidelines, these women were treated according to recommendations for high-grade squamous intraepithelial lesions (HSIL).
The second study found that the NMP179 assay from Matritech (Newton, MA), used to diagnose cervical cancer, identified 92% of high-risk cases among 869 women with Pap smear results that were previously classified as indeterminate (ASCUS) but were later diagnosed with high-grade squamous intraepithelial lesions in follow-up.
NMP179 detected 92 percent of ASCUS cases (46/50) that were later diagnosed with high-grade squamous intraepithelial lesions (HSIL) via tissue biopsy or follow-up cytology.
The authors report a statistically significant increase in the detection of high-grade squamous intraepithelial lesions (HSIL) in patients screened with the ThinPrep Pap Test compared to those screened with the conventional smear.