DLBCL is an aggressive (fast-growing) and high-grade lymphoma
that can arise in nodal or extranodal sites, such as gastrointestinal tract, testes, thyroid, skin, breast, bone, or brain.
In our study, VEGF-A and CD31 staining were evaluated as markers of tumor vascularity in lymph nodes, showing significant difference in terms of MVD between high-grade lymphoma
(DLBCL), which demonstrated high MVD, and low-grade FL, which showed low MVD.
Additionally, since the standard approach to a newly diagnosed, high-grade lymphoma
is immediate intervention with aggressive chemotherapy, this treatment paradigm may have precluded other cases with the potential for spontaneous remission.
Most dogs with intermediate to high-grade lymphoma
are responsive to chemotherapy.
Without treatment, cats with high-grade lymphoma
usually live only four to six weeks.
Since FL can transform to high-grade lymphoma
, therefore patients with lymph node biopsy proven transformation were taken into account.
(ii) Lymphoepithelial lesions in MALT-type lymphoma involve transitional epithelium, and their presence in high-grade lymphoma
suggests a primary origin owing to transformation of low-grade MALT-type lymphoma.
Life-threatening medical emergencies include TTP and tumour lysis syndrome in high-grade lymphoma
; these require urgent hospitalisation and management.
Diagnosis of DLBCL, Burkitt's lymphoma, plasmablastic lymphoma and high-grade lymphoma
were confirmed independently on review by two authors (DA and JCM) using morphologic and immunohistochemical criteria defined in the WHO classification.
Tingible-body macrophages (akin to the 'starry sky' appearance seen with Burkitt's lymphoma) and mitotic figures indicative of a high-grade lymphoma
are readily seen [39,61,62].
Transformation to a high-grade lymphoma
occurs in 25 to 35% of patients.
There were no clear differences in trends in the ORs between B-cell and T-cell subtypes, but the increasing risk of NHL with the number of years worked in pesticide-related jobs and with the cumulative number of any pesticide product uses around the home was most pronounced for high-grade lymphoma
(p < 0.001 and p = 0.002, respectively).