However, the optimal timing of epinephrine administration is unknown.[sup] High-dose epinephrine is not recommended (Class III recommendation).[sup]
The effect of standard- and high-dose epinephrine on coronary perfusion pressure during prolonged cardiopulmonary resuscitation.
(29) Collen reviewed and reported 59 cases of finger injection with high-dose epinephrine
of which 32 cases were untreated.
Hickey added that high-dose epinephrine
is not recommended in children, based on a study showing that it did not improve return of spontaneous circulation and resulted in worse 24-hour survival (New Engl.
The use of high-dose epinephrine
for pulseless arrests is de-emphasized in children.