high-dose chemotherapy


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high-dose chemotherapy

Oncology The administration of chemotherapeutics in excess of BM toxicity; given the risk of aplastic anemia, HDC requires autologous BMT and use of 'rescue' factors such as G-CSF, GM-CSF, and erythropoietin. See Bone marrow transplantation.
References in periodicals archive ?
Phase III randomized trial of conventional-dose chemotherapy with or without high-dose chemotherapy and autologous hematopoietic stem-cell rescue as first-line treatment for patients with poor-prognosis metastatic germ cell tumors.
Five women had died due to causes that were clearly related to their high-dose chemotherapy, said Dr.
TI-CE high-dose chemotherapy for patients with previously treated germ cell tumors: Results and prognostic factor analysis.
Up until fairly recently, the strategy of high-dose chemotherapy followed by stem cell transplantation enjoyed significant support among oncologists, but that sup port has now waned.
First, it proved that Response Oncology's IMPACT centers network is extremely capable of successfully conducting a demanding Phase 3 analysis of two high-dose chemotherapy regimens.
Cancer study under way: To help resolve an ongoing controversy in cancer care, the National Cancer Institute (NCI) has launched the first large national study to compare the effectiveness of high-dose chemotherapy for ovarian cancer with conventional chemotherapy.
For example, in the evaluation of various applications of high-dose chemotherapy and bone marrow transplantation, the patient's willingness to assume a high level of risk with uncertain but potential benefits has clashed with managed care companies' greater emphasis on knowledge of potential benefits.
High-dose chemotherapy plus stem-cell transplantation offers no survival advantage over conventional chemotherapy for women with metastatic breast cancer, reported Dr.
ECRI, a nonprofit health services research organization and Collaborating Center of the World Health Organization offers a Patient Reference Guide on high-dose chemotherapy with bone marrow transplant and/or peripheral stem cell for metastatic breast cancer.
29 /PRNewswire/ -- Today the Medical Advisory Panel (MAP) of the Blue Cross and Blue Shield Association's (BCBSA) Technology Evaluation Center (TEC) issued a revised assessment of high-dose chemotherapy with autologous bone marrow transplant (ABMT) for the treatment of metastatic breast (stage IV) cancer.
Within the past year, numerous states have introduced bills that would mandate insurance coverage for investigational cancer therapies - in particular high-dose chemotherapy and bone marrow transplant for breast cancer.

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