Polaprezinc prevents oral mucositis in patients treated with high-dose chemotherapy
followed by hematopoietic stem cell transplantation.
Phase III randomized trial of conventional-dose chemotherapy with or without high-dose chemotherapy
and autologous hematopoietic stem-cell rescue as first-line treatment for patients with poor-prognosis metastatic germ cell tumors.
Five women had died due to causes that were clearly related to their high-dose chemotherapy
, said Dr.
and stem-cell rescue for metastatic germ-cell tumors.
Up until fairly recently, the strategy of high-dose chemotherapy
followed by stem cell transplantation enjoyed significant support among oncologists, but that sup port has now waned.
But based on the current data, "the information from these studies does not suggest that high-dose chemotherapy
with transplants improves survival," Dr.
For example, in the evaluation of various applications of high-dose chemotherapy
and bone marrow transplantation, the patient's willingness to assume a high level of risk with uncertain but potential benefits has clashed with managed care companies' greater emphasis on knowledge of potential benefits.
An experimental treatment that combines high-dose chemotherapy
with stem cell transplantation (HDC+SCT) does little or nothing to extend the lives of women with breast cancer that has spread to their lymph nodes, according to 2 studies in the July 3 issue of the New England Journal of Medicine.
plus stem-cell transplantation offers no survival advantage over conventional chemotherapy for women with metastatic breast cancer, reported Dr.
Within the past year, numerous states have introduced bills that would mandate insurance coverage for investigational cancer therapies - in particular high-dose chemotherapy
and bone marrow transplant for breast cancer.
Some oncologists envision high-dose chemotherapy
becoming an outpatient procedure when coupled with CSFs.