high molecular weight kininogen


Also found in: Acronyms.

high mo·lec·u·lar weight ki·nin·o·gen (HMWK),

a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.

high mo·lec·u·lar weight ki·nin·o·gen

(HMWK) (hī mŏ-lek'yū-lăr wāt ki-nin'ō-jen)
A plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.
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