high molecular weight kininogen


Also found in: Acronyms.

high mo·lec·u·lar weight ki·nin·o·gen (HMWK),

a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.

high mo·lec·u·lar weight ki·nin·o·gen

(HMWK) (hī mŏ-lek'yū-lăr wāt ki-nin'ō-jen)
A plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.
References in periodicals archive ?
Bromelain has been demonstrated to inhibit thrombus formation when administered orally and intravenously.15,16 The effect may be related to reduction in levels of high molecular weight kininogen and weak release of thrombin.
Integrated by 3 serine proteases, factor XII (FXII), factor XI (FXI), and plasma prekallikrein (PK) and by one nonenzymatic cofactor, high molecular weight kininogen (HK), the kallikrein-kinin system (KKS), also referred to as the plasma contact pathway of coagulation, is assembled and activated when the blood comes in contact with negatively charged
Kunapuli et al., "High molecular weight kininogen binds to Mac-1 on neutrophils by its heavy chain (domain 3) and its light chain (domain 5)," Journal of Biological Chemistry, vol.

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