There are no known cases of hibernoma
metastases or malignant transformation [2, 5].
(1) typical (nonlipoma type), with more than 70% multivacuolated adipocytes, which is the most common form of hibernoma
(82%) that occurs most frequently in the thigh,
Only 18 cases of cervical hibernoma
have been reported to our knowledge in the literature 7.
(3) In 1914, the actual term hibernoma
was coined when Gery recognized a histologic resemblance between these tumors and the brown fat identified in hibernating animals.
In conclusion, giant liposarcomas in scapular region are extremely rare; and possible differential diagnosis may be lipoma, lipoblastoma, pleomorphic lipoma, chondroid lipoma, hibernoma
and neurofibroma etc.
steroid cell tumors, fibrothecomas, or any benign tumor with abundant adipose tissue Malignant: Well-differentiated liposarcomas, adrenal cortical carcinomas, clear cell RCCs, or any malignant tumor with abundant adipose tissue Prosthetic groups Tumors with high content of mitochondria or (protoporphyrin cytochromes necessary for redox reactions ring + metal atom) Heme and Benign: Renal oncocytoma, hepatic cytochromes: adenoma, hibernoma
(also carotenes), protoporphyrin + oncocytic tumors in other organs: salivary iron gland (oncocytoma, Warthin tumor), ACTH-producing pituitary adenoma, Hurthle cell adenoma, some parathyroid adenomas?
The differential diagnosis of GCT includes rhabdomyoma, hibernoma
, oncocytoma, extragastrointestinal stromal tumor (EGIST), and the reactive changes associated with trauma and injury.
Imaging studies can distinguish encapsulated fat (progressive nodular lipomatosis and multiple hereditary lipomas, hibernoma
) from Madelung disease by means of fat suppression and chemical shift imaging.
is a benign lipomatous tumor made of brown fat, a specialized form of adipose tissue.
Large retroperitoneal hibernoma
: CT findings with pathologic correlation.
The differential diagnosis includes other primary soft tissue neoplasms, such as rhabdomyoma, hibernoma
, clear cell sarcoma of soft tissue, perivascular epithelioid cell neoplasm (PEComa), paraganglioma, and granular cell tumor.