Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. Curr Probl Cardiol 2001; 26:147-186.
Comparison of baseline nitrate technetium-99m sestamibi with rest-redistribution thallium-201 tomography in detecting viable hibernating myocardium and predicting postrevascularization recovery.
The researchers cleverly circumvented the problem of having no human survivors to study by creating the hibernating myocardium
phenomenon in the first animal model--a pig--for the disease, and implanting a defibrillator similar to that used in patients with advanced heart disease.
Immunohistochemical staining and internucleosomal laddering in myocytes from hibernating myocardium
. Animal (pig) Stenosis % apoptotic Intern ucleosomal protocol myocytes laddering 1 <24 h 0.274 Yes 2 24 h 6.684 Yes 3 24 h 2.755 No 4 7 days 2.51 No 5 4 wks 1.885 No
In a canine model, Kim et al (8) reported that infarcts exhibited hyperenhancement whether acute or chronic, whereas stunned or hibernating myocardium did not.
Comparison of 201Tl, 99mTc-tetrofosmin, and dobutamine magnetic resonance imaging for identifying hibernating myocardium. Circulation.
Tracer uptake should increase in the distribution of hibernating myocardium supplied by a patent coronary artery.
However, it is now known that functional recovery may not occur until as long as 6 months after revascularization in patients with hibernating myocardium (in contradistinction to those with only stunning).
For the differentiation of scarred versus hibernating myocardium, the patient groups studied in most reported series include those with chronic coronary artery disease.