BIRC3

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BIRC3

A gene on chromosome 11q22 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. BIRC3 acts by binding to tumour necrosis factor receptor-associated factors TRAF1 and TRAF2, interfering with activation of ICE-like proteases.
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Jang, "UVB-induced anti-survival and proapoptotic effects on HaCaT human keratinocytes via caspaseand PKC-dependent downregulation of PKB, HIAP-1, Mcl1, XIAP and ER stress," International Journal of Molecular Medicine, vol.
(44) Some of the up-regulated genes are involved in intercellular interactions (ICAM1, ELAM-ligand), intercellular signaling (IL-8, GM-CSF, FGF-5), and increased cell survival (antiapoptotic: hIAP-1, FLICE-like inhibitory protein).