Production of the hexitol
D- mannitol by Cryptococcus neoformansin vitro and in rabbits with experimental meningitis.
Gastrointestinal hormones, such as gastrin, neurotensin, cholecystokinin and pancreatic polypeptide, are also increased and result in vagal stimulation of smooth muscle fibres.[sup.74] Chewing gum also increases secretion of saliva and pancreatic juices, and a recent study proposed that sorbitol and hexitol
found in sugar-free gum may also play a role in the reduction of postoperative ileus.[sup.75] A number of studies exist which demonstrate the benefits in patients undergoing colorectal surgery.[sup.73,74,76]-[sup.78] A meta-analysis of several RCTs evaluating the effect of chewing gum on postoperative ileus has subsequently been published.
Experiments using [sup.14]C with species of fungi known to contain large amounts of mannitol have generally shown that the hexitol
is a primary product of heterotrophic assimilation (LEWIS, 1971).
Cocero, "Supercritical water hydrolysis of cellulosic biomass as effective pretreatment to catalytic production of hexitols
and ethylene glycol over Ru/MCM-48," Green Chemistry, vol.
Investigation on the mechanism by fructose, hexitols
and other compounds regulate the translocation of glucokinase in rat hepatocytes.
Recently, it has been proposed that hexitols
present in sugarless chewing gums might also be playing a role in the amelioration of POI because these are known to cause gastrointestinal symptoms such as gas, bloating, and abdominal cramps in a dose-dependent manner.
The patent is named 'Method of Synthesis of Substituted Hexitols
Such as Dianydrogalactitol' and has a patent term that lasts until 2030.
Cheng et al., "The hydrogenation/dehydrogenation activity of supported Ni catalysts and their effect on hexitols
selectivity in hydrolytic hydrogenation of cellulose," Journal of Catalysis, vol.
In addition, sugar free chewing gum that contains the artificial sweetener sorbitol and other hexitols
might be having side effects such as bloating, gas, and abdominal cramps.