hexamethonium


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hexamethonium

(hĕks″ă-mĕ-thō′nē-ŭm)
A compound that acts as a ganglionic blocking agent, used to treat hypertension.
References in periodicals archive ?
Hexamethonium is potent and essentially devoid of neuromuscular blocking activity by a nicotinic receptor-blocking agent that blocks ion channels of the autonomic ganglia, resulting in blockage of the outputs of the sympathetic pathways [53, 54].
As the extract did not alter blood pressure after administration of losartan and hexamethonium, it can be suggested that the hypotensive action of the extract implicates the AT1R mechanism and sympathetic ganglionic blockade.
Acetylcholine chloride, atropine sulfate, dimethylsulfondioxide (DMSO), hexamethonium bromide, isoproterenol hemisulfate, nicotine, (Sigma Chemicals Co, St.
Experiments designed to study the effect of hexamethonium (1 [micro]M) on [alpha]-hederin-induced contraction, started with a 1 h equilibration.
There's a lot at stake: whether one is an aspiring Watson or Crick at a university without a first-rate library, a doctor in a meningitis laboratory in Zimbabwe, or even just a participant in a Johns Hopkins study on hexamethonium. With so little to lose, the more information the better.
Drugs: The following agents were used: Acetylcholine chloride (Merck), Phentolamine methanesulfonate (CIJ3A Geigy), methoxamine hydrochloride (Burroughs Wellcome Co.), isoproterenol hydrochloride (Sigma), propranolol hydrochloride (Sigma), atropine (Sigma) and hexamethonium chloride (K & K Laboratories, Inc.).
When hexamethonium was given, the hypotensive response to the extract was diminished in a significant way (p < 0.05) (Fig 2).
Injection of the well-characterized muscle nicotinic acetylcholine receptor antagonist hexamethonium at concentrations of millimoles per liter through the soft tissue surrounding the mouth and into the coelom led to a clear decrease in the tone of the tube feet and significantly slowed righting time about fivefold (Fig.
The first response was accompanied by a rise in systemic blood pressure, which was reduced by hexamethonium, not entirely eliminated by phentolamine but eliminated with spinal destruction to the sacral cord level.
The ACh antagonist hexamethonium inhibited both the excitatory and inhibitory effects of ACh, but had no effect on contractions induced by 5HT and DA.
MCAF was more potent than ACPF in contracting the colon, Hexamethonium (2.8 X [10.sup.-8] M), chlorpheniramine (3.8 X [10.sup.-8] M) and promethazine (3.2 X [10.sup.-10] M) potentiated the effect of ACPF on the colon.
injection of the ganglion blocker, hexamethonium (30 mg/kg body wt.), were significantly greater in DOCA-salt-hypertensive than in control rats.