heterozygous


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het·er·o·zy·gous

(het'ĕr-ō-zī'gŭs),
Having different alleles at a given locus on the pair of chromosomes present in the diploid state; for example, having a normal beta globin gene (coding for normal hemoglobin, Hb A) at locus p15.5 on one chromosome 11 and an abnormal gene (coding for sickle-cell hemoglobin, Hb S) at the same locus on the other chromosome 11.

heterozygous

(hĕt′ər-ə-zī′gəs)
adj.
1. Having different alleles at one or more corresponding chromosomal loci.
2. Of or relating to a heterozygote.

het′er·o·zy·gos′i·ty (-ə-rō-zī-gŏs′ĭ-tē) n.

heterozygous

[het′ərəzī′gəs]
Etymology: Gk, heteros + zygotos, yoked
having two different alleles at corresponding loci on homologous chromosomes. An individual who is heterozygous for a trait has inherited an allele for that trait from one parent and an alternative allele from the other parent. An individual who is heterozygous for a genetic disease caused by a dominant allele, such as Huntington's disease, manifests the disorder. A person who is heterozygous for a hereditary disorder produced by a recessive allele, such as sickle cell anemia, is asymptomatic or exhibits reduced symptoms of the disease. The offspring of a heterozygous carrier of a genetic disorder have a 50% chance of inheriting the allele associated with the disorder if the other parent does not carry the allele. Compare homozygous.

het·er·o·zy·gous

(het'ĕr-ō-zī'gŭs)
Having different allelic genes at one locus or (by extension) many loci; heterotic.

heterozygous

Of a person carrying different genes at the same gene locus in corresponding chromosomes. The ALLELES are different. A single DOMINANT gene can manifest itself in a heterozygous person. Recessive genes are only manifest if both are present (HOMOZYGOUS).

Heterozygous

Two different genes controlling a specified inherited trait.

heterozygous

expression of inheritance of genetic disease, where the individual inherits the causative gene from only one parent, i.e. overt disease is not expressed or is expressed in mild form only in heterozygous indidivuals; see homozygous

het·er·o·zy·gous

(het'ĕr-ō-zī'gŭs)
Having different alleles at a given locus on the pair of chromosomes present in the diploid state.

heterozygous (het´ərōzī´gus),

adj a term indicating that genes lying at equivalent loci on chromosome pairs are different.

heterozygous

having different alleles at the one locus.
References in periodicals archive ?
The disorders are classified by the globin genes that are mutated (for example, alpha versus beta) and by the severity of disease, which is related to whether mutations are inherited in a heterozygous or a homozygous/compound heterozygous fashion.
The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations.
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial.
who investigated the relatioship of omentin-1 gene Val109Asp polymorphism and CAD in Turkish population but found no significant association reason might be recruitment of small number of CAD patients, however, it was observed that Val/Val heterozygous genotype was more frequent in CAD patients.
No evidence of publication bias was found in case of heterozygous Arg/Gly, homozygous Glu, and homozygous Gly.
35delG mutations were found in four families, heterozygous c.
Fibroblasts were cultured from ear skin biopsies of the heterozygous [alpha]GT KO piglets as previously reported [2].
He was found to exhibit compound heterozygous GNRHR mutations, Gln106Arg and Arg262Gln.
Evolocumab has been studied in heterozygous familial hypercholesterolaemia (RUTHERFORD-2), primary hypercholesterolaemia/mixed dyslipidaemia as combination therapy with statin (LAPLACE-2, MENDEL-2), primary hypercholesterolaemia/ mixed dyslipidaemia in Japanese (YUKAWA-2), statin intolerants patients (GAUSS-2) and primary hypercholesterolaemia/mixed dyslipidaemia as monotherapy (MENDEL-2).
At current prices, PCSK9 inhibitors are not cost effective for patients with heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease, according to an analysis published Aug.
In another presentation, researchers looking at the "Long-term safety, tolerability and efficacy of evolocumab in patients with heterozygous familial hypercholesterolaemia," found that treatment with Repatha for 48 weeks resulted in persistent and marked LDL-C reductions in these patients.
Global Markets Direct's, 'Heterozygous familial hypercholesterolemia (heFH) - Pipeline Review, H1 2016', provides an overview of the Heterozygous familial hypercholesterolemia (heFH) pipeline landscape.