heterozygosity


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Related to heterozygosity: Loss of heterozygosity

heterozygosity

 [het″er-o-zi-gos´ĭ-te]
the state of having different alleles in regard to a given character. adj., adj heterozy´gous.

het·er·o·zy·gos·i·ty

, heterozygosis (het'ĕr-ō-zī-gos'i-tē, -zī-gō'sis),
The state of being heterozygous.
[hetero- + G. zygon, a yoke]

het·er·o·zy·gos·i·ty

, heterozygosis (het'ĕr-ō-zī-gos'i-tē, -zī-gō'sis)
The state of being heterozygous.
[hetero- + G. zygon, a yoke]

heterozygosity

The state of possessing two different ALLELES for one or more genes. Loss of heterozygosity from all the abnormal cells in a lesion indicates monoconal proliferation and is a molecular marker of neoplasia.
References in periodicals archive ?
Intra-population heterozygosity and analysis of inbreeding coefficient: FIS and heterozygosity of Chinese pond turtle were estimated for each population by12 microsatellite loci (table 6).
The average heterozygosity of both Pakistani sheep breeds is lower than Chinese goat populations 0.677 to 0.737 (49) and 0.77 to 0.821 (50) and higher then some of the Indian goat and sheep breed values 0.426 and 0.501 (9, 51).
The Fixation Index (F), or Inbreeding coefficient, or Heterozygosity deficit, showed that the cultured population possessed excess heterozygosity with a negative coefficient of -0.173 [+ or -] 0.209, perhaps due to selection for heterozygotes through negative assortative mating.
Although there were no significant differences between values, the contrasting heterozygosity (Ho) between the two populations evidenced higher heterozygosity (Ho) in adults and sub-adults from the JNP, and lower heterozygosity (Ho) in both categories from the urban parks, fact that reveals the inbreeding process in fragmented populations (Table 1).
High levels of expected heterozygosity can be attributed to some factors such level of inbreeding, low selection pressure and high allele number.
Subsequently NPR2 heterozygosity has been identified in patients evaluated for ISS in studies by Wang et al.
Here, we present a first report of inadvertent transplantation of a liver from a donor with C282Y/H63D compound heterozygosity into a nonhemochromatotic recipient.
Of these, the mutations p.Asn76Thr and p.Cys698Arg were detected in compound heterozygosity with the most frequently detected mutation c.5714+5G>A (intron 40) in one male (ABCA4-47A, Supplementary Figures 1A and B) and one female patient (ABCA4-27A, Supplementary Figures 2A and B), respectively.
The five polymorphisms used included DdeI which is previously reported to be the most prevalent among neighboring Indian population.9 The current study reconfirms the heterozygosity rate of DdeI in Pakistani HB population of Khyber Pakhtunkhwa (KP) province and Federally Administered Tribal Areas (FATA).
Allele frequencies, heterozygosity values, and polymorphism information content (PIC) of each marker were determined by genotyping genomic DNA samples from 2 ethnic populations.
Alleles were scored using GeneMapper software (Applied Biosystems) and Saga[TM] software (LI-COR) then inputted into POPGENE (Yeh and Boyle, 1997) for analysis of observed and expected heterozygosity and allelic variation.
The founder effect on genetic variability of experimental populations of mosquito fish were measured by the allozymes electrophoretic technique by Leberg (1992), who estimated the values of proportion of polymorphic loci, number of alleles per locus and heterozygosity. Compared to source populations, Leberg found that 23 populations had a smaller He and 15 had an equal or greater He.