heterotopic ossification


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myositis ossificans

A term that is slowly being retired from the medical literature, largely in favour of heterotopic ossification, given that
(1) inflammation is not a necessary precursor for heterotopic ossification; and
(2) the ossification doesn’t always occur in muscle, but may occur in fascia, tendons, and other mesenchymal soft tissues.

Clinical forms, myositis ossificans
• Localised: linked to trauma.
• Generalised: now known as fibrodysplasia ossificans progressiva, which is often due to spontaneous mutation, resulting in autosomal dominant pattern of inheritance in the proband’s progeny.

het·er·o·top·ic os·si·fi·ca·tion

(het'ĕr-ō-top'ik os'i-fi-kā'shŭn)
Growth of calcium deposits within soft tissue, usually at the site of a hematoma due to blunt trauma or in tissue atrophied due to central nervous system injury.
Synonym(s): myositis ossificans.

heterotopic ossification

The development of mature lamellar bone in soft tissue that does not normally contain bone. The condition is usually associated with trauma in or around a joint or following severe head or spinal cord injuries. Heterotopic ossification is also found in the rare autosomal dominant condition of MYOSITIS OSSIFICANS.
References in periodicals archive ?
Potential risk factors for developing heterotopic ossification in patients with severe traumatic brain injury.
Heterotopic ossification in complex orthopaedic combat wounds: quantification and characterization of osteogenic precursor cell activity in traumatized muscle.
PHP-Ia can be differentiated from this syndrome only by the presence of GNAS mutation and of heterotopic ossifications (8).
To our knowledge, there are no reports describing heterotopic ossification occurring secondary to a gunshot wound in birds.
Continuous passive motion in the management of heterotopic ossification in a brain injured patient.
Heterotopic ossification after total knee arthroplasty.
(3) As it was the case in our patient, scoliosis is the end result of this heterotopic ossification that occurs more on one side.
Induction of Heterotopic Ossification with Bone Morphogenetic Protein-2
To clarify the mechanism of heterotopic ossification in this case of adrenal ML, immunohistochemical analysis was performed using anti-BMP2 (1:250, Abcam, Cambridge, MA) and anti-[beta]-catenin (1:500, BD Biosciences, UK) antibodies.
Heterotopic ossification in metastatic colorectal carcinoma: case report with morphoproteomic insights into the histogenesis.
Heterotopic ossification was graded according to the criteria established by Brooker et al.