Daptomycin is an alternative to vancomycin for patients with MRSA infections, but some authors have recommended to use high doses to minimize the emergence of elevated MIC values, which has been associated with an increase in the vancomycin MIC and the heteroresistant
sup], Furthermore, heteroresistant
isolates might result from the coexistence of wild type and mutant alleles of the gyrA gene at the preliminary stage of full-drug resistance.
It was shown that heteroresistant
populations may become fully resistant after continuous exposure to colistin ([1,5]).
pdf), including a previously reported heteroresistant
Klebsiella pneumoniae isolate for which MIC for colistin was high (12).
Clinical features of heteroresistant
vancomycin-intermediate staphylococcus aureus bacteremia versus those of methicillin-resistant s.
Outcome of heteroresistant
Staphylococcus aureus infections in children.
38] The appropriate dose must exceed an MIC of 2 mg/L rapidly to prevent regrowth of more resistant organisms in heteroresistant
populations, in which the PK target achieved would be insufficient for eradication.
Prevalence and characteristics of heteroresistant
Vancomycin- Intermediate Staphylococcus aureus Bacteremia in a tertiary care center.
Most importantly, it runs a greater risk of failing to detect heteroresistant
strains, a phenomenon in which the variability in culture conditions may affect phenotypic expression of resistance.
to vancomycin, or that may have been selected on treatment, e.
58% of personal saying were carrying from heteroresistant
strains SARM in nasal graves.
The mechanism is known as "hVISA" for heteroresistant
vancomycin intermediate Staphylococcus aureus.