heteroresistance

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heteroresistance

(hĕt″ĕr-ō-rĭ-zĭs′tĭns) [″ + ″]
The presence within a population of a pathogen of some organisms that are susceptible to an antimicrobial drug and some that are not. Heteroresistance may explain why failure to eradicate an infection occurs in some patients treated with a seemingly appropriate antibiotic.
heteroresistant, adjective
References in periodicals archive ?
Daptomycin is an alternative to vancomycin for patients with MRSA infections, but some authors have recommended to use high doses to minimize the emergence of elevated MIC values, which has been associated with an increase in the vancomycin MIC and the heteroresistant phenotype (hVISA).
sup][13],[34] Furthermore, heteroresistant isolates might result from the coexistence of wild type and mutant alleles of the gyrA gene at the preliminary stage of full-drug resistance.
pdf), including a previously reported heteroresistant Klebsiella pneumoniae isolate for which MIC for colistin was high (12).
Clinical features of heteroresistant vancomycin-intermediate staphylococcus aureus bacteremia versus those of methicillin-resistant s.
38] The appropriate dose must exceed an MIC of 2 mg/L rapidly to prevent regrowth of more resistant organisms in heteroresistant populations, in which the PK target achieved would be insufficient for eradication.
Prevalence and characteristics of heteroresistant Vancomycin- Intermediate Staphylococcus aureus Bacteremia in a tertiary care center.
Most importantly, it runs a greater risk of failing to detect heteroresistant strains, a phenomenon in which the variability in culture conditions may affect phenotypic expression of resistance.
aureus heteroresistant to vancomycin, or that may have been selected on treatment, e.
The mechanism is known as "hVISA" for heteroresistant vancomycin intermediate Staphylococcus aureus.