to colistin in Klebsiella pneumoniae associated with alterations in the PhoPQ regulatory system.
3 Interestingly, in this study, all strains were found sensitive to colistin, whereas up to 50% heteroresistance
to colistin has been reported globally.
In addition, the presence of wild-type sequence along with the corresponding mutant probe indicated the sample carrying heteroresistance
to colistin in multidrug-resistant Acinetobacter baumannii.
Introduction: Colistin can be used in patients infected with carbapenem-resistant Acinetobacter baumannii complex (CR-ABC), but recently resistance to colistin and heteroresistance
have been reported.
13) The presence of WT along with MUT bands in RIF-resistant isolates expressed either heteroresistance
or mixed infection.
1] Although MDR-AB strains are generally susceptible to colistin, colistin monotherapy may cause in vitro heteroresistance
Digital PCR to detect and quantify heteroresistance
in drug resistant Mycobacterium tuberculosis.
in Bloodstream Isolates of Staphylococcus capitis.
Absence of known mutations in these resistant strains might be an indication to the presence of other rare rpoB mutations heteroresistance
(a mixed infection of susceptible and resistant subpopulations), or less likely another mechanism of resistance to rifampicin (BArtfai et al.
Characterization of heteroresistance
to fluconazole among clinical isolates of Cryptococcus neoformans.
8) The MRSA isolates in our series were not available for tolerance or heteroresistance
testing, but all had MICs to vancomycin of less than or equal to 1 [micro]g/mL.