Dopazo and colleagues noticed that many of the plants had more than one type of chloroplast DNA in their cells, a phenomenon known as heteroplasmy
The consequence of these multiple ways of mixing and assorting mtDNA both within a single mitochondrion and the collected mitochondria of the cell as a whole leads to the concepts of homoplasmy (where all mitochondrial genomes in a cell or organism are of the same sequence) and heteroplasmy
(where two or even more mitochondrial genome types can be present simultaneously in an organism).
11) The level of heteroplasmy
in different cells and tissues can usually determine the phenotype of mitochondrial disorders.
But occasionally a cell can have a mix of normal and mutant mitochondrial DNA, a condition called heteroplasmy
They are actually mixed type of the alleles due to the heteroplasmy
of the mitochondrial genome.
Additionally, localized mtDNA heteroplasmy
and diversity patterns suggest that one of the most severely contaminated sites in Sumgayit is acting as a source of new mutations resulting from an increased mutation rate.
in European populations of the mussel Mytilus trossulus.
Furthermore, the unparalleled sensitivity of this assay allows for detection of heteroplasmy
Development of a novel next-gen sequencing (NGS) methodology for accurate characterization of genome-wide mitochondrial heteroplasmy
in human embryo (O-196) Kathleen Hong Oral - Tuesday 5:00-5:15 p.
We are currently further evaluating extension of this oligonucleotide array CGH approach to the simultaneous analysis of copy number mutations in nuclear genes, mitochondrial DNA depletion, and single deletions in the mitochondrial genome leading to heteroplasmy
occurs when not all mtDNA copies within a given cell are identical.
Such variation is a rare condition called heteroplasmy