IgSF CAMs are involved in complex extracellular interactions involving both homophilic and heterophilic
binding to CAMs as well as multiple cis and trans interactions .
Amato et al., "Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic
binding by serum rheumatoid factor," Arthritis and Rheumatism, vol.
The extracellular domains of the CEACAM group function as homophilic and heterophilic
cellular adhesion molecules or receptors [32-34].
Integrins or proteases released by the stimulation of PECAM-1 and its heterophilic
activity, which allowed leukocytes to transmigrate through basement membrane, will change the properties of endothelial cells.
These molecules can either form homophilic or heterophilic
Severe histiolymphocytic and heterophilic
bronchopneumonia as a vaccination in broiler chicks reaction to in ovofowlpox.
High TSH levels as an artifact due to circulating heterophilic
antibodies against thyrotropin.
Rodriguez et al., "Heterophilic
NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: results of a phase Ib/IIa study," Cancer Biology and Therapy, vol.
The presence of heterophilic
antibodies in high titers may lead to analytical errors in two-site immunoassays (2).
Histopathologically it was characterized by congestion, oedema, mononuclear and heterophilic
cell infiltration in the dermal layer.
Expression of CD6, a heterophilic
receptor for ALCAM expressed mainly in lymphocytes, has not been determined in the uterine endometrium or conceptuses in pigs so far, but it is possible that ALCAM may recruit and activate endometrial lymphocytes.