Forssman antibody

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Related to heterophile antibody: heterophile antigen

Fors·sman an·ti·bod·y

a heterogenetic antibody specific for the Forssman group of heterogenetic antigens.

Fors·sman an·ti·bod·y

(fōrs'măn an'tē-bodē)
Molecule found in the blood of patients with infectious mononucleosis.


John, Swedish bacteriologist and pathologist, 1868-1947.
Forssman antibody - a heterogenetic antibody specific for the Forssman group of heterogenetic antigens. Synonym(s): heterophil antibody; heterophile antibody
Forssman antigen - the antibody that develops in infectious mononucleosis reacts specifically with the Forssman antigen.
Forssman antigen-antibody reaction - the combination of Forssman antibody with heterogenetic antigen of the Forssman type. Synonym(s): Forssman reaction
Forssman reaction - Synonym(s): Forssman antigen-antibody reaction
References in periodicals archive ?
Children with acute infectious mononucleosis were diagnosed by symptoms, >10% atypical lymphocytes, and a positive heterophile antibody test.
It is correct, that for the purposes of the algorithm, we have assumed that all persons with a positive heterophile antibody test had infectious mononucleosis and did not need to be routinely evaluated further virologically.
In addition, a control group that consisted of a selection of 50 patients from the 1689 original patients who were heterophile antibody negative but who had a normal lymphocyte count and generated no atypical lymphocyte flag were also tested for EBV IgM antibodies.
To investigate whether heterophile antibody interference was a cause for the discrepant results, we incubated 11 consecutive discrepant samples (between September 7, 2011, and September 15, 2011) in Scantibodies HBT tubes.
Although the heterophile antibody test may occasionally be false positive in patients with autoimmune diseases, serum sickness, pregnancy, or HIV infection, false negatives are far more frequent (about 15% overall), particularly in children who are under 4 years of age (approximately 45%).
56%) were classified as outliers, and no heterophile antibody interference was identified with this assay.
As illustrated in this clinical case, heterophile antibody blocking tubes can be used to eliminate the interference, although this approach does not always eliminate the interference.
On the other hand, the absence of such a TSH increase in the patient as recently as 4 months earlier suggested no heterophile antibody interference.
Heterophile antibody binding to the variable region of the assay antibody (idiotypic interaction) is less common (5).
1) published in this issue of Clinical Chemistry describes the clinical work-up of a patient with low-positive human chorionic gonatodtropin (hCG) due to pituitary or heterophile antibody interference.
Care has been taken to block such activities at heterophile antibody titers commonly encountered in a population, but rare samples with higher titers may affect the test.
Phantoms in the assay tube: heterophile antibody interferences in serum thyroglobulin assay.