heteroduplex


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het·er·o·du·plex

(het'ĕr-ō-dū'pleks),
1. A DNA molecule, the two constitutive strands of which derive from distinct sources and hence are likely to be somewhat mismatched.
2. A DNA-RNA hybrid.
[hetero- + L. duplex, two-fold]

heteroduplex

[-do̅o̅′pleks]
Etymology: Gk, heteros + L, duoplicare, to double
a DNA molecule in which the two strands are derived from different individuals, with the result that some base pairs may not be complementary.

het·er·o·du·plex

(het'ĕr-ō-dū'pleks)
1. A DNA molecule, the two constitutive strands of which derive from distinct sources and hence are likely to be somewhat mismatched.
2. A DNA-RNA hybrid.
[hetero- + L. duplex, two-fold]

heteroduplex

a DUPLEX DNA in which the two strands do not show COMPLEMENTARY BASE PAIRING throughout, but instead contain one or more MISMATCHES OF BASES. A heteroduplex may be formed during RECOMBINATION, for example. Compare HOMODUPLEX.
References in periodicals archive ?
Pathway Diagnostics' heteroduplex tracking technology is an important new advance that highlights the growing importance of diagnostics to personalized medicine," said Joyce G.
In fact, we found no evidence of interspecific hybridization using diagnostic COI and ITS-1 markers, even though formation of ITS-1 heteroduplex bands in hybrids would have facilitated identification of the most likely interspecific hybrids from the C.
Heteroduplex resolution using T7 endonuclease I in microbial community analyses.
Later on, more efficient methods have been discovered including heteroduplex analysis (Sitte et al.
The heteroduplex fragment in the heterozygote, post-restriction-reaction pool arises from annealing of some of the 187 base-pair fragments from the parent of D.
We analysed the BRCA2 gene using a novel high-throughput multiplex fluorescence heteroduplex detection system developed for the ABI3130xl genetic analyzer.
In 1968, while still a graduate student at the California Institute of Technology, he developed one of the first mapping methods for DNA, as well as heteroduplex technology, which made imaging the pairing of two genomes possible.
Although, investigators have applied different methods (Gene Scanning and Heteroduplex gel electrophoresis) to detect rearrangements, both approaches have similar sensitivities in clonality PCR assays [14].
The physical parameters tested were the G + C content of the fragment, the position of the variant within the fragment, and the specific nature of the heteroduplex mismatch (single-base variants only).
Using sensitive tests for fidelity of amplification, including sequencing and heteroduplex analysis, Sanger scientists have found the quality of OmniPlex DNA to be comparable to that of natural human DNA.