To prove this effect, researchers exposed xanthohumol-supplemented healthy rats to a common family of dietary carcinogens (called heterocyclic
amines) that forms when meat is cooked at high temperatures.
Chemistry of Heterocyclic
Compounds: Synthesis of Fused Heterocycles.
Results from these two large prospective cohort studies do not support the hypothesis that higher intake of heterocyclic
amine intake per se substantially increases risk of CRC.
2,3-Dihydroimidazo[1,5-b]pyrazoles 84 containing a structurally heterocyclic
system corresponding to cyclized histamine were prepared by cyclodehydration of substituted N-(3-pyrazolylmethyl)acetamides 80 or N-(3-pyrazolylmethyl)acetamides 83, obtained by the catalytic hydrogenation of 1-benzoyl-4,5-dihydro-1H-pyrazole-3-carbonitriles 79 followed by acylation.
amines form in grilled, charbroiled, or fried meat in two essential steps.
Latest Developments in the Analysis of Heterocyclic
Amines in Cooked Foods.
The data showed that all the meat samples marinated in red wine or beer contained lower levels of heterocyclic
amines than the control.
The compounds, heterocyclic
amines, form when food is cooked at high temperatures.
The company has entered into an agreement with Heterocorporation (Provo, UT) to publish the "Journal of Heterocyclic
Chemistry" beginning with Vol.
In a laboratory, they tested the white blood cells of subjects before and after drinking coffee, subjecting the ceils to two different kinds of cell-damaging substances: hydrogen peroxide, a free radical, and heterocyclic
aromatic amine, a cancer-causing substance produced when certain foods are cooked.
But Carl Baum, M.D., wants parents to be aware of the delicate balance they must achieve between cooking burgers on the grill long enough to protect against bacterial contamination and not cooking them so long as to produce large amounts of heterocyclic
amines (HCAs), proven human carcinogens.
Grilling of frying meat and poultry can create heterocyclic
amines, which may cause cancer.