herpetic keratitis


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Related to herpetic keratitis: herpetic whitlow

her·pet·ic ker·a·ti·tis

inflammation of the cornea (or cornea and conjunctiva) due to herpes simplex virus.

herpetic keratitis

her·pet·ic ker·a·ti·tis

(hĕr-pet'ik ker'ă-tī'tis)
Inflammation of the cornea (or cornea and conjunctiva) due to herpes simplex virus.
Synonym(s): herpes corneae, herpetic keratoconjunctivitis.

keratitis

inflammation of the cornea. Keratitis may be deep, when the infection causing it is carried in the blood or spreads to the cornea from other parts of the eye, or superficial, caused by bacterial or viral infection, trauma, or by allergic reaction. The clinical signs include pain, blepharospasm, ocular discharge, and when chronic, pigmentation.

chronic superficial keratitis
a progressive cellular infiltration with vascularization and eventually pigmentation of the cornea that usually commences at the temporal (lateral) quadrant and advances towards the center. The whole cornea may become involved. It occurs in dogs, particularly German shepherd dogs. The cause is unknown, but exposure to ultraviolet light may be a factor. Cellular infiltrates suggest immune mechanisms are involved in the pathogenesis. Called also CSK, degenerative pannus, Uberreiter's syndrome.
eosinophilic keratitis
a superficial neovascularization and cellular infiltration of the cornea, beginning at the temporal limbus, in adult cats. Eosinophils and plasma cells are found in conjunctival or corneal scrapings and biopsies, and a peripheral eosinophilia is sometimes present. The cause is unknown, but it may be immune-mediated.
exposure keratitis
keratitis resulting from ineffective or incomplete closure of the eyelids with drying of the corneal tear film. Occurs in paralysis of the eyelids, brachycephalic dogs with prominent globes, and cats during ketamine anesthesia. See also lagophthalmos.
herpetic keratitis
herpesvirus infections of the cornea occur in feline and bovine rhinotracheitis infections, and are suspected in dogs. In cats there may be ulcerative keratitis with dendritic ulcers; in cattle conjunctivitis is more common than keratitis.
infectious keratitis
interstitial keratitis
inflammation of the substantia propria, causing dense corneal clouding.
mycotic keratitis
neurotrophic keratitis, neuroparalytic keratitis
a chronic keratopathy resulting from impairment of the sensory (trigeminal) innervation of the cornea.
keratitis nigrum
see corneal sequestrum.
keratitis sicca
superficial diffuse keratitis
see chronic superficial keratitis (above).
superficial pigmentary keratitis
a pigmentation of epithelium and superficial stroma of the cornea, resulting from chronic keratitis from a variety of causes. Seen most commonly in brachycephalic dogs in which the contributing factors are exposure keratitis, distichiasis, irritation from the nasal folds and sometimes keratoconjunctivitis sicca.
superficial punctate keratitis
a keratopathy with discrete opacities of the cornea, without ulceration. Can be caused by irritation.
ulcerative keratitis
see corneal ulcer.
References in periodicals archive ?
Sirion Ophthalmologist Emeritus and renowned herpetic keratitis researcher and clinician.
Sirion's pipeline includes four late-stage opportunities: ganciclovir, a topical antiviral for herpetic keratitis which is awaiting an NDA filing in early 2008; difluprednate, a potent topical steroid in Phase III development for post-operative inflammation and uveitis; cyclosporine, a topical immunomodulator in Phase III testing for dry eye and fenretinide, a first-in-class oral vitamin A binding protein antagonist in Phase II development for geographic atrophy associated with dry AMD.
The company has raised $75 million to date and is currently developing a portfolio of product candidates that includes therapies in the areas of inflammatory diseases and conditions, allergy, dry eye, herpetic keratitis and dry age-related macular degeneration.
The company is currently developing a portfolio of product candidates that includes therapies in the areas of inflammatory diseases and conditions, allergy, dry eye, herpetic keratitis and dry age-related macular degeneration.